Favorable outcome of ovarian germ cell malignancies treated with cisplatin or carboplatin-based chemotherapy: a Hellenic Cooperative Oncology Group study
Φόρτωση...
Ημερομηνία
Συγγραφείς
Dimopoulos, M. A.
Papadopoulou, M.
Andreopoulou, E.
Papadimitriou, C.
Pavlidis, N.
Aravantinos, G.
Aspropotamitis, A.
Anagnostopoulos, A.
Fountzilas, G.
Michalas, S.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Gynecol Oncol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
PURPOSE: To evaluate the outcome and the prognosis of patients with ovarian germ cell malignancies who were treated with platinum-based chemotherapy immediately after initial surgery. METHODS: We conducted a retrospective review of patients with ovarian germ cell tumors who were referred for consideration of treatment to the Departments of Medical Oncology participating in the Hellenic Cooperative Oncology Group. RESULTS: Over a 14-year period 53 patients were included in our study. There were 13 patients with dysgerminoma and 40 patients with nondysgerminomatous tumors. Forty percent of patients underwent complete resection of their tumors. Platinum-based chemotherapy consisted primarily of cisplatin, vinblastine, and bleomycin (PVB) in 9 patients; bleomycin, etoposide, and cisplatin (BEP) in 15 patients; and bleomycin, etoposide, and carboplatin (BEC) in 25 patients. With a median follow-up of 39 months, 5 patients developed progressive disease and died of their tumor and 1 patient died of bleomycin-induced lung toxicity with no evidence of active tumor. The 5-year overall survival was 100% for patients with dysgerminoma and 85% for patients with nondysgerminomatous tumors. Eighty percent of patients with advanced nondysgerminomatous tumors and residual disease after surgery remain disease free. CONCLUSION: With this study we confirm that patients with ovarian germ cell malignancies have a favorable outcome when treated with platinum-based chemotherapy.
Περιγραφή
Λέξεις-κλειδιά
Adolescent, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols/*therapeutic use, Bleomycin/administration & dosage, Carboplatin/administration & dosage, Child, Cisplatin/administration & dosage, Etoposide/administration & dosage, Female, Germinoma/*drug therapy/mortality, Humans, Middle Aged, Ovarian Neoplasms/*drug therapy/mortality, Prognosis, Retrospective Studies, Survival Rate, Treatment Outcome, Vinblastine/administration & dosage
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/9698477
http://ac.els-cdn.com/S0090825898950478/1-s2.0-S0090825898950478-main.pdf?_tid=dd41b84f66bee70e20534f81b50e53b7&acdnat=1333610946_0a6f73602903b5eb54943d8eb120d0e7
http://ac.els-cdn.com/S0090825898950478/1-s2.0-S0090825898950478-main.pdf?_tid=dd41b84f66bee70e20534f81b50e53b7&acdnat=1333610946_0a6f73602903b5eb54943d8eb120d0e7
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής