Immunohistochemical expression of retinoblastoma gene product (Rb), p53 protein, MDM2, c-erbB-2, HLA-DR and proliferation indices in human urinary bladder carcinoma

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dc.contributor.authorIoachim, E.en
dc.contributor.authorCharchanti, A.en
dc.contributor.authorStavropoulos, N. E.en
dc.contributor.authorSkopelitou, A.en
dc.contributor.authorAthanassiou, E.en
dc.contributor.authorAgnantis, N. J.en
dc.date.accessioned2015-11-24T19:11:55Z
dc.date.available2015-11-24T19:11:55Z
dc.identifier.issn0213-3911-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20982
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectAntigens, Nuclearen
dc.subjectFemaleen
dc.subjectHLA-DR Antigens/*biosynthesisen
dc.subjectHumansen
dc.subjectImmunoenzyme Techniquesen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNuclear Proteins/biosynthesisen
dc.subjectProliferating Cell Nuclear Antigen/*biosynthesisen
dc.subjectProto-Oncogene Proteins/*biosynthesisen
dc.subjectProto-Oncogene Proteins c-mdm2en
dc.subjectReceptor, erbB-2/*biosynthesisen
dc.subjectRetinoblastoma Protein/*biosynthesisen
dc.subjectTumor Markers, Biologicalen
dc.subjectTumor Suppressor Protein p53/*biosynthesisen
dc.subjectUrinary Bladder Neoplasms/*metabolism/pathologyen
dc.titleImmunohistochemical expression of retinoblastoma gene product (Rb), p53 protein, MDM2, c-erbB-2, HLA-DR and proliferation indices in human urinary bladder carcinomaen
heal.abstractArchival biopsy specimens from transitional cell bladder cancers (n=88) were analysed immunohistochemically for the expression of the retinoblastoma (Rb) gene protein, p53, mdm2, c-erbB-2, HLA-DR antigen and proliferation indices. An altered nuclear expression of Rb, p53 and mdm2 was observed in 55.2%, 33.3% and 18.2% of tumors respectively. Cytoplasmic membrane immunoreactivity (>25% tumor cells) for c-erbB-2 was detected in 14.1% of tumors and aberrant HLA-DR antigen cytoplasmic staining (>5% of tumor cells) in 22.2% of the cases. P53 overexpression was associated with higher tumor grade and stage. Aberrant HLA-DR antigen expression and PCNA were also correlated with the grade of differentiation and tumor stage. MIB1 was statistically correlated with stage. pRb scores and HLA-DR antigen expression were correlated with proliferation activity as determined by PCNA and MIB1 immunostaining. p53 protein was also strongly correlated with the proliferation index PCNA. A strong correlation between PCNA and MIB1 (p<0.0001) was also found. In addition a statistically positive correlation between p53 and HLA-DR antigen expression was observed. Our data show that, although pRb and p53 protein expressions are not associated between them, they may contribute to the growth fraction of the bladder cancer. In addition, p53 and HLA-DR antigen expression could be indicators of aggressive behavior of bladder cancer.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/10963116-
heal.journalNameHistol Histopatholen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2000-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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