Synthesis, X-ray characterisation and studies of the new ionic complex [bis(pyridin-2-yl) disulfide] triiodide, obtained by oxidation of 2-mercaptopyridine with I-2 - Implications in the mechanism of action of antithyroid drugs
| dc.contributor.author | Antoniadis, C. D. | en |
| dc.contributor.author | Hadjikakou, S. K. | en |
| dc.contributor.author | Hadjiliadis, N. | en |
| dc.contributor.author | Kubicki, M. | en |
| dc.contributor.author | Butler, I. S. | en |
| dc.date.accessioned | 2015-11-24T16:49:53Z | |
| dc.date.available | 2015-11-24T16:49:53Z | |
| dc.identifier.issn | 1434-1948 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/9541 | |
| dc.rights | Default Licence | - |
| dc.subject | bioinorganic chemistry | en |
| dc.subject | iodine complexes | en |
| dc.subject | polyiodides | en |
| dc.subject | s ligands | en |
| dc.subject | crystal structures | en |
| dc.subject | charge-transfer complexes | en |
| dc.subject | i iodothyronine deiodinase | en |
| dc.subject | crystal-structures | en |
| dc.subject | molecular-interactions | en |
| dc.subject | diiodine adducts | en |
| dc.subject | ft-raman | en |
| dc.subject | iodine | en |
| dc.subject | methimazole | en |
| dc.subject | imidazole-2-thiones | en |
| dc.subject | interhalogens | en |
| dc.title | Synthesis, X-ray characterisation and studies of the new ionic complex [bis(pyridin-2-yl) disulfide] triiodide, obtained by oxidation of 2-mercaptopyridine with I-2 - Implications in the mechanism of action of antithyroid drugs | en |
| heal.abstract | The reaction of 2-mercaptopyridine (C5H5NS or PYSH) with diiodine in a molar ratio of 1:2 in dichloromethane led to the oxidation and dimerization of the ligand and formation of [(PYS-PYSH)I-+.(3)-]. The compound was characterised by elemental analysis, DTA-TG, FT-Raman, FT-IR, UV/Vis and H-1 NMR spectroscopy. The crystal structure of the complex has been determined by X-ray diffraction at 293(2) K. The compound [(C5H4NS-SNC5H5)I-3] is monoclinic with the space group P2(1) and a = 8.230(2) Angstrom, b = 35.708(7) Angstrom, c = 11.369(2) Angstrom, beta = 91.86(3)degrees and Z = 8. The results are discussed in relation to the mechanism of action of antithyroid drugs. The easy oxidation of PYSH by I-2 to form the monocationic disulfide complex [(PYS-PYSH)I-+.(3)-] is similar to the case of the antithyroid drug methimazole (MMI) and may indicate that PYSH might also possess antithyroid properties similar to those of MMI. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | DOI 10.1002/ejic.200400290 | - |
| heal.identifier.secondary | <Go to ISI>://000225259900021 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1002/ejic.200400290/asset/4324_ftp.pdf?v=1&t=h0dvkpks&s=cca98d506dc4a84a6bad8dd9bbd4d8ff8e05b537 | - |
| heal.journalName | European Journal of Inorganic Chemistry | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2004 | - |
| heal.publisher | Wiley-VCH Verlag | en |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
Files
License bundle
1 - 1 of 1
Loading...
- Name:
- license.txt
- Size:
- 1.74 KB
- Format:
- Item-specific license agreed upon to submission
- Description: