Expression of apoptosis-inducing factor (AIF) in keratoacanthomas and squamous cell carcinomas of the skin
| dc.contributor.author | Skyrlas, A. | en |
| dc.contributor.author | Hantschke, M. | en |
| dc.contributor.author | Passa, V. | en |
| dc.contributor.author | Gaitanis, G. | en |
| dc.contributor.author | Malamou-Mitsi, V. | en |
| dc.contributor.author | Bassukas, I. D. | en |
| dc.date.accessioned | 2015-11-24T19:16:50Z | |
| dc.date.available | 2015-11-24T19:16:50Z | |
| dc.identifier.issn | 1600-0625 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/21713 | |
| dc.rights | Default Licence | - |
| dc.subject | Apoptosis | en |
| dc.subject | Apoptosis Inducing Factor/*metabolism | en |
| dc.subject | Carcinoma, Squamous Cell/*metabolism/pathology | en |
| dc.subject | Cell Nucleus/metabolism/pathology | en |
| dc.subject | Humans | en |
| dc.subject | In Situ Nick-End Labeling | en |
| dc.subject | Keratoacanthoma/*metabolism/pathology | en |
| dc.subject | Microscopy, Fluorescence | en |
| dc.subject | Retrospective Studies | en |
| dc.subject | Skin Diseases/*metabolism/pathology | en |
| dc.subject | Skin Neoplasms/*metabolism/pathology | en |
| dc.title | Expression of apoptosis-inducing factor (AIF) in keratoacanthomas and squamous cell carcinomas of the skin | en |
| heal.abstract | The complex biological trait 'susceptibility to apoptosis' is a nosological feature distinguishing squamous cell carcinomas (SCC) from keratoacanthomas (KA). The purpose of this study was to compare the expression of apoptosis-inducing factor (AIF), a major effector of the caspase-independent apoptosis pathway, in formalin-fixed SCC (N = 23) and KA (N = 29) resection specimens. SCC express statistically significant more AIF than KA both as proportion of AIF+ cells by immunohistochemistry (median: 54% vs 33%; P < 0.01) and as total AIF protein content by western blot quantification (six-fold increased; P < 0.01). However, the contribution of AIF to apoptosis, measured as fraction of apoptotic nuclei with overt DNA fragmentation by the TUNEL method that co-express AIF translocated to nucleus, is significantly less prevalent among SCC (median: 19% vs 48% in KA; P < 0.01). These findings indicate to a distinctive involvement of AIF in the progression of certain epithelial skin tumors that might be exploited as a promising treatment target. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1111/j.1600-0625.2011.01249.x | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/21410769 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1111/j.1600-0625.2011.01249.x/asset/j.1600-0625.2011.01249.x.pdf?v=1&t=h0f0wycm&s=90e2bf5f7540aaa230bfc3ccbc79a31c6fd1b1ff | - |
| heal.journalName | Exp Dermatol | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2011 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
Αρχεία
Φάκελος/Πακέτο αδειών
1 - 1 of 1
Φόρτωση...
- Ονομα:
- license.txt
- Μέγεθος:
- 1.74 KB
- Μορφότυπο:
- Item-specific license agreed upon to submission
- Περιγραφή: