Synthesis, characterization, crystal structures, in vitro and in vivo antitumor activity of palladium(II) and zinc(II) complexes with 2-formyl and 2-acetyl pyridine N(4)-1-(2-pyridyl)-piperazinyl thiosemicarbazone
Φόρτωση...
Ημερομηνία
Συγγραφείς
Kovala-Demertzi, D.
Alexandratos, A.
Papageorgiou, A.
Yadav, P. N.
Dalezis, P.
Demertzis, M. A.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Polyhedron
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
The present paper includes synthesis and spectral characterization of the novel prepared palladium(B) and zinc(II) complexes with 2-formyl pyridine N(4)-1-(2-pyridyl)-piperazinyl thiosemicarbazone, HFo4Npypipe, 1 and the 2-acetyl pyridine N(4)-1-(2-pyridyl)-piperazinyl thiosemicarbazone, HAc4Npy-pipe, 2. The Pd(II) complexes [PdCl(Fo4Npypipe)], 3, [PdCl(Ac4Npypipe)], 4 and the Zn(II) complexes [ZnCl(2)(Fo4Npypipe)], 5 and [ZnCl(2)(Ac4Npypipe)], 6 have been characterized by elemental analyses and spectroscopic studies. The crystal structure of the complexes [PdCl(Fo4Npippy)], 3 and [PdCl(Ac4N-pippy)], 4, have been solved by single-crystal X-ray diffraction. The electronic, IR, UV/Vis, and NMR spectroscopic data of the complexes are reported. The results of the cytotoxic activity of 1-6 have been evaluated in vitro against the cells of three human cancer cell lines: MCF-7, T24, A-549 and a mouse L-929 (a fibroblast-like cell line cloned from strain Q. For selected compounds 2 and 6 the acute toxicity and antitumor activity were evaluated on leukemia P388-bearing mice. The Zn(II) compounds 5 and 6 are considered as agents with potential antitumor activity, and can therefore be candidates for further stages of screening in vitro and/or in vivo. (C) 2008 Elsevier Ltd. All rights reserved.
Περιγραφή
Λέξεις-κλειδιά
palladium(ii, zinc(ii)) complexes, thiosemicarbazonato complexes, crystal structure, spectroscopic studies, anti-tumor activity, rapid colorimetric assay, platinum(ii) complexes, spectral properties, pyridine-2-carbaldehyde thiosemicarbazone, 4n-ethyl thiosemicarbazone, antiproliferative activity, ribonucleotide reductase, biological-activity, cytotoxic activity, cell-lines
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000259712800001
http://ac.els-cdn.com/S0277538708002003/1-s2.0-S0277538708002003-main.pdf?_tid=b969958c254690ffdf03f24d51f96f20&acdnat=1333028645_531cdd149caf8b6d809a1733899a0fb6
http://ac.els-cdn.com/S0277538708002003/1-s2.0-S0277538708002003-main.pdf?_tid=b969958c254690ffdf03f24d51f96f20&acdnat=1333028645_531cdd149caf8b6d809a1733899a0fb6
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας