Interaction of Cu(II) and Ni(II) with the 63-93 fragment of histone H2B

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dc.contributor.authorZavitsanos, K.en
dc.contributor.authorNunes, A. M. P. C.en
dc.contributor.authorMalandrinos, G.en
dc.contributor.authorKallay, C.en
dc.contributor.authorSovago, I.en
dc.contributor.authorMagafa, V.en
dc.contributor.authorCordopatis, P.en
dc.contributor.authorHadjiliadis, N.en
dc.date.accessioned2015-11-24T16:40:13Z
dc.date.available2015-11-24T16:40:13Z
dc.identifier.issn1477-9226-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/8247
dc.rightsDefault Licence-
dc.subjectc-terminal tailen
dc.subjectmetal-binding sequenceen
dc.subjectaromatic ring stackingen
dc.subjectbeta-amyloid peptideen
dc.subjectcopper(ii) complexesen
dc.subjectoxidative damageen
dc.subjectsolid-phaseen
dc.subjectcoordination propertiesen
dc.subjecthistidyl residuesen
dc.subjectalpha-synucleinen
dc.titleInteraction of Cu(II) and Ni(II) with the 63-93 fragment of histone H2Ben
heal.abstractChromatin proteins are believed to represent reactive sites for metal ion binding. We have synthesized the 31 amino acid peptide Ac-NSFVNDIFERIAGEASRLAHYNKRSTITSRE-NH(2), corresponding to the 63-93 fragment of the histone H2B and studied its interaction with Cu(II) and Ni(II). Potentiometric and spectroscopic studies (UV-vis, CD, NMR and EPR) showed that histidine 21 acts as an anchoring binding site for the metal ion. Complexation of the studied peptide with Cu(II) starts at pH 4 with the formation of the monodentate species CuH(2)L. At physiological pH values, the 3N complex {N(Im), 2N(-)}, CuL is favoured while at basic pH values the 4N {N(Im), 3N(-)} coordination mode is preferred. Ni(II) forms several complexes with the peptide starting from the distorted octahedral NiH(2)L at about neutral pH, to a square planar complex where the peptide is bound through a {N(Im), 3N(-)} mode in an equatorial plane at basic pH values. These results could be important in revealing more information about the mechanism of metal induced toxicity and carcinogenesis.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDoi 10.1039/B810354b-
heal.identifier.secondary<Go to ISI>://000260644000016-
heal.identifier.secondaryhttp://pubs.rsc.org/en/content/articlepdf/2008/dt/b810354b-
heal.journalNameDalton Transactionsen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2008-
heal.publisherRoyal Society of Chemistryen
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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