Association of Helicobacter pylori infection with cardiovascular disease--is it just a myth?
Φόρτωση...
Ημερομηνία
Συγγραφείς
Christodoulou, D. K.
Milionis, H. J.
Pappa, P.
Katsanos, K. H.
Sigounas, D.
Florentin, M.
Elisaf, M. S.
Tsianos, E. V.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Eur J Intern Med
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
OBJECTIVE: To test the hypothesis that Helicobacter pylori infection is associated with a higher rate of documented cardiovascular disease (CVD) in subjects undergoing elective upper gastrointestinal endoscopy. METHODS: 202 consecutive patients (median age 60 years, 101 men) were studied. H. pylori infection was established by a rapid urease test in a gastric tissue sample (CLO test) and by histological examination of gastric mucosa from the stomach antrum and body. CVD was documented by completion of the Rose questionnaire. The association of H. pylori infection with CVD was determined by multivariate logistic regression modelling after adjusting for potential confounding factors. RESULTS: A total of 104 (51.5%) subjects were found H. pylori positive. Forty patients had a confirmed history of CVD. Multiple logistic regression analysis verified the strong associations of CVD with established risk factors of atherosclerotic disease but not with H. pylori infection. CONCLUSION: Our findings suggest that there is no association of H. pylori infection with CVD. Eradication of H. pylori to prevent CVD is not warranted.
Περιγραφή
Λέξεις-κλειδιά
Adult, Age Factors, Aged, Atherosclerosis/etiology, Cardiovascular Diseases/etiology/*microbiology, Diabetes Complications, *Endoscopy, Gastrointestinal, Female, Helicobacter Infections/*complications, *Helicobacter pylori, Humans, Hypertension/complications, Logistic Models, Male, Middle Aged, Obesity, Abdominal/complications, Questionnaires, Risk Factors, Upper Gastrointestinal Tract/*pathology
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/21402252
http://ac.els-cdn.com/S0953620510002311/1-s2.0-S0953620510002311-main.pdf?_tid=52dfb3a3167f7621e7502152e1ca29f8&acdnat=1333949312_972476ef5e7bcc7e73364a741aa74c82
http://ac.els-cdn.com/S0953620510002311/1-s2.0-S0953620510002311-main.pdf?_tid=52dfb3a3167f7621e7502152e1ca29f8&acdnat=1333949312_972476ef5e7bcc7e73364a741aa74c82
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής