Arginine deiminase inhibits cell proliferation by arresting cell cycle and inducing apoptosis

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dc.contributor.authorGong, H.en
dc.contributor.authorZolzer, F.en
dc.contributor.authorvon Recklinghausen, G.en
dc.contributor.authorRossler, J.en
dc.contributor.authorBreit, S.en
dc.contributor.authorHavers, W.en
dc.contributor.authorFotsis, T.en
dc.contributor.authorSchweigerer, L.en
dc.date.accessioned2015-11-24T19:35:39Z
dc.date.available2015-11-24T19:35:39Z
dc.identifier.issn0006-291X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23722
dc.rightsDefault Licence-
dc.subjectApoptosis/*drug effectsen
dc.subjectArginine/metabolismen
dc.subjectCell Cycle/*drug effectsen
dc.subjectCell Division/drug effectsen
dc.subjectCell Nucleus/drug effects/metabolismen
dc.subjectCells, Cultureden
dc.subjectDNA Fragmentation/drug effectsen
dc.subjectDose-Response Relationship, Drugen
dc.subjectEndothelium, Vascular/cytology/drug effectsen
dc.subjectHumansen
dc.subjectHydrolases/*pharmacologyen
dc.subjectMycoplasma/enzymologyen
dc.subjectSignal Transduction/drug effectsen
dc.subjectTumor Cells, Cultureden
dc.titleArginine deiminase inhibits cell proliferation by arresting cell cycle and inducing apoptosisen
heal.abstractWe have previously demonstrated that arginine deiminase inhibits the proliferation of vascular endothelial cells, but the mechanisms leading to growth inhibition have remained unclear. We report here that low concentrations of arginine deiminase purified from Mycoplasma arginini inhibit proliferation of various cultured cells by arresting the cell cycle in G(1) and/or S phase with higher arginine deiminase concentrations leading to subsequent apoptosis. Our results demonstrate that arginine deiminase inhibits cell proliferation not only by depletion of arginine, but also by mechanisms involving the cell cycle and death signals.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1006/bbrc.1999.1004-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/10405315-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0006291X99910045/1-s2.0-S0006291X99910045-main.pdf?_tid=dc0c73c6d2f1534b37a30a6e6a1bbc2f&acdnat=1332752222_81de9796e5217e916a1846b1cb1bafe7-
heal.journalNameBiochem Biophys Res Communen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1999-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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