Interaction of antimony(III) chloride with thiourea, 2-mercapto-5-methyl-benzimidazole, 3-methyl-2-mercaptobenzothiazole, 2-mercaptopyrimidine, and 2-mercaptopyridine
Loading...
Date
Authors
Ozturk, I. I.
Kourkoumelis, N.
Hadjikakou, S. K.
Manos, M. J.
Tasiopoulos, A. J.
Butler, I. S.
Balzarini, J.
Hadjiliadis, N.
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Type
Type of the conference item
Journal type
peer reviewed
Educational material type
Conference Name
Journal name
Journal of Coordination Chemistry
Book name
Book series
Book edition
Alternative title / Subtitle
Description
New antimony(III) chloride complexes with heterocyclic thioamides, thiourea (TU), 2-mercapto-5-methyl-benzimidazole (MMBZIM), 3-methyl-2-mercaptobenzothiazole (MMBZT), 2-mercaptopyrimidine (PMT), 2-mercaptopyridine (PYT) of formulae [SbCl3(TU)(2)] (1), [SbCl3(MMBZIM)(2)] (2), [SbCl3(MMBZT)(2)] (3), [SbCl3(PMT)(2)] (4), [SbCl3(mu(2)-S)(PYT)(2)] (5) were synthesized and characterized by elemental analysis, FT-IR and FT-Raman spectroscopies, and TG-DTA analysis. The crystal structure of 5 was also determined by X-ray diffraction. [C10H10Cl3N2S2Sb] (5) crystallizes in space group C2/c, with a = 25.0169(10) angstrom, b = 9.7952(3) angstrom, c = 12.9329(5) angstrom, beta = 109.702(4)degrees, and Z = 8. Crystals of 5 grown from acetonitrile solutions adopt a square-pyramidal geometry. The equatorial plane is formed by three chlorides and one sulfur atom from the thione ligand while the second sulfur is axial. The complexes were evaluated for their biological activities and compared with [SbCl3(MMI)(2)] (6) (MMI = 2-mercapto-1-methylimidazole) and other isostructural ones. The complexes showed moderate cytostatic activity against murine leukemia cells (L1210), murine mammary carcinoma cells (FM3A), human T-lymphocyte (Molt4/C8, CEM), and human cervix carcinoma (HeLa) cells. The chloro and iodo derivatives show better cytostatic activity than the bromo ones.
Description
Keywords
bioinorganic chemistry, antimony(iii) chloride complexes, thioamides, crystal structure, cytotoxic activity, crystal-structure, in-vitro, diphenylantimony(iii) derivatives, structural-characterization, molecular-structure, x-ray, complexes, spectroscopy, thioamides, density
Subject classification
Citation
Link
<Go to ISI>://000299471200002
http://www.tandfonline.com/doi/pdf/10.1080/00958972.2011.633603
http://www.tandfonline.com/doi/pdf/10.1080/00958972.2011.633603
Language
en
Publishing department/division
Advisor name
Examining committee
General Description / Additional Comments
Institution and School/Department of submitter
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας