Relationship of shear stress with in-stent restenosis: Bare metal stenting and the effect of brachytherapy
Φόρτωση...
Ημερομηνία
Συγγραφείς
Papafaklis, M. I.
Bourantas, C. V.
Theodorakis, P. E.
Katsouras, C. S.
Fotiadis, D. I.
Michalis, L. K.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Elsevier
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Int J Cardiol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Background: The association of shear stress (SS) with in-stent restenosis after bare metal stenting is not clear. We investigated the significance of SS on predicting areas with neointima thickness (NT) in humans and the effect of vascular brachytherapy (VBT) following coronary artery stenting on the relationship of SS with NT. Methods: By using coronary angiography and intravascular ultrasound, we performed three-dimensional (3D) artery and stent reconstruction in 14 patients at 8-month follow-up after bare metal stenting with (stent&VBT group; 7 patients) or without (stent group; 7 patients) adjunctive beta-VBT. In-stent SS was calculated by applying computational fluid dynamics to the stent reconstruction and NT was determined in 3D space. Results: NT was significantly increased in the stent group (0.2 +/- 0.16 mm vs. 0.07 +/- 0.18 mm, p<0.001). The estimated intercepts and slopes regarding the relationship of NT with SS were 0.28 mm [95% confidence interval (CI): 0.20 to 0.36 mm, p<0.001] and -0.057 mm/Pa (95% CI: -0.062 to -0.052 mm/Pa, p<0.001) respectively for the stent group, and 0.15 mm (95% CI: -0.02 to 0.31 mm, p=0.082) and -0.017 mm/Pa (95% CI: -0.023 to -0.010 mm/Pa, p<0.001) respectively for the stent&VBT group. After pooling all data together, a significant effect of VBT on the relationship between NT and SS was found [ estimate of interaction term (group x SS) for stent&VBT vs. stent group: 0.04 mm/Pa; 95% CI: 0.032 to 0.049 mm/Pa, p<0.001]. Conclusions: In-stent restenosis is inversely related to SS after coronary artery stenting and VBT diminishes the inverse relationship between NT and SS. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
Περιγραφή
Λέξεις-κλειδιά
stents, intravascular ultrasound, three-dimensional reconstruction, computational fluid dynamics, hemodynamics, radiation therapy, human coronary-arteries, intravascular ultrasound images, angiographic follow-up, balloon angioplasty, beta-radiation, intracoronary brachytherapy, cell-proliferation, 3d reconstruction, border detection, blood-flow
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000265079500005
http://ac.els-cdn.com/S0167527308003744/1-s2.0-S0167527308003744-main.pdf?_tid=cc1e6d630d10abaa1cc679ecc87caa25&acdnat=1339758338_ea1bc49e2a3acd3cf192c4264f10c6e6
http://ac.els-cdn.com/S0167527308003744/1-s2.0-S0167527308003744-main.pdf?_tid=cc1e6d630d10abaa1cc679ecc87caa25&acdnat=1339758338_ea1bc49e2a3acd3cf192c4264f10c6e6
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Μηχανικών Επιστήμης Υλικών