The value of 99mTc-tetrofosmin brain SPECT in predicting survival in patients with glioblastoma multiforme
Φόρτωση...
Ημερομηνία
Συγγραφείς
Alexiou, G. A.
Tsiouris, S.
Kyritsis, A. P.
Fotakopoulos, G.
Goussia, A.
Voulgaris, S.
Fotopoulos, A. D.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J Nucl Med
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
(99m)Tc-tetrofosmin brain SPECT has been reported as a useful tool for the evaluation of glioma proliferation. In the present study, we set out to investigate the prognostic value of (99m)Tc-tetrofosmin brain SPECT in patients with glioblastoma multiforme. METHODS: We prospectively studied 18 patients (13 men, 5 women; mean age +/- SD, 60.8 +/- 7.79 y) who were operated on for glioblastoma multiforme. All patients underwent preoperative (99m)Tc-tetrofosmin brain SPECT, and surgical excision was performed within a week after SPECT. All patients received postoperative radiotherapy and chemotherapy. RESULTS: By calculating the lesion-to-normal (L/N) (99m)Tc-tetrofosmin uptake ratio, we found that patients with an L/N ratio of more than 4.7 had significantly worse survival than did patients with an L/N ratio of 4.7 or less. Furthermore, patients with a Karnofsky Performance Score more than 90 had a significantly better survival rate. Although patients with near-total tumor resection who were younger than 60 y survived longer, the difference did not reach statistical significance. In the multivariate analysis, (99m)Tc-tetrofosmin uptake and Karnofsky Performance Score were identified as factors with independent prognostic power. CONCLUSION: (99m)Tc-tetrofosmin brain SPECT may be an independent prognostic factor in patients with glioblastoma multiforme. Further larger studies are needed to verify these results.
Περιγραφή
Λέξεις-κλειδιά
Aged, Brain/*radionuclide imaging, Brain Neoplasms/*radionuclide imaging/*therapy, Female, Flow Cytometry, Glioblastoma/*radionuclide imaging/*therapy, Humans, Image Interpretation, Computer-Assisted, Immunohistochemistry, Kaplan-Meier Estimate, Karnofsky Performance Status, Ki-67 Antigen/analysis, Male, Middle Aged, Organophosphorus Compounds/*diagnostic use, Organotechnetium Compounds/*diagnostic use, Predictive Value of Tests, Radiopharmaceuticals/*diagnostic use, Survival Analysis, Tomography, Emission-Computed, Single-Photon
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/21078797
http://jnm.snmjournals.org/content/51/12/1923.full.pdf
http://jnm.snmjournals.org/content/51/12/1923.full.pdf
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής