Behavioural and dopaminergic alterations induced by a low dose of WIN 55,212-2 in a conditioned place preference procedure

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dc.contributor.authorPolissidis, A.en
dc.contributor.authorChouliara, O.en
dc.contributor.authorGalanopoulos, A.en
dc.contributor.authorMarselos, M.en
dc.contributor.authorPapadopoulou-Daifoti, Z.en
dc.contributor.authorAntoniou, K.en
dc.date.accessioned2015-11-24T19:33:17Z
dc.date.available2015-11-24T19:33:17Z
dc.identifier.issn1879-0631-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23522
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectAvoidance Learning/drug effectsen
dc.subjectBehavior, Animal/*drug effects/physiologyen
dc.subjectBenzoxazines/*pharmacologyen
dc.subjectCalcium Channel Blockers/*pharmacologyen
dc.subjectCannabinoids/*agonistsen
dc.subjectCentral Nervous System Stimulants/pharmacologyen
dc.subjectConditioning, Classical/*drug effectsen
dc.subjectDextroamphetamine/pharmacologyen
dc.subjectDopamine/*metabolismen
dc.subjectDopamine Uptake Inhibitors/pharmacologyen
dc.subjectMorpholines/*pharmacologyen
dc.subjectMotor Activity/drug effectsen
dc.subjectNaphthalenes/*pharmacologyen
dc.subjectOrientation/drug effectsen
dc.subjectRatsen
dc.subjectRats, Sprague-Dawleyen
dc.titleBehavioural and dopaminergic alterations induced by a low dose of WIN 55,212-2 in a conditioned place preference procedureen
heal.abstractAIMS: This study investigated the role of the cannabinoid CB1 receptor agonist, WIN 55,212-2, on motor activity. Subsequently, the effects of a low, stimulatory dose of WIN 55,212-2 and cocaine, as a positive control, were evaluated using a conditioned place preference (CPP) procedure. Upon completion of CPP, in rats that had been treated with WIN 55,212-2, dopaminergic status and spontaneous and d-amphetamine-induced motor activity were assessed. MAIN METHODS: Sprague-Dawley rats were evaluated for habituated motor activity following WIN 55,212-2 (0, 0.1, 0.3, 1 mg/kg, i.p.) administration. A stimulatory dose of WIN 55,212-2 (0.1 mg/kg, i.p.) and cocaine (20 mg/kg, i.p.) was selected to assess CPP behaviour. Upon completion of CPP, in one group, tissue levels of dopamine and its metabolites were measured in distinct brain regions (dorsal striatum, nucleus accumbens, prefrontal cortex, amygdala, hippocampus) using High Performance Liquid Chromatography with electrochemical detection. In another group, spontaneous and D-amphetamine-induced motor activity was evaluated in an open-field apparatus. KEY FINDINGS: The lowest dose of WIN 55,212-2 increased motor activity but did not produce CPP. As expected, cocaine induced clear CPP. Dopaminergic status was increased in a region-specific way and motor activity was enhanced following a challenge of D-amphetamine in rats that had been administered with WIN 55,212-2 during conditioning. SIGNIFICANCE: A stimulatory effect of WIN 55,212-2 on motor activity was not accompanied by place preference. Upon completion of the CPP procedure, this dose was found to induce region-specific hyperdopaminergia along with a greater sensitivity to a subsequent challenge dose of D-amphetamine.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.lfs.2009.05.015-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19508876-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0024320509002537/1-s2.0-S0024320509002537-main.pdf?_tid=dc749347b469ed1490f7d7beca4547b7&acdnat=1332926271_c41c7405b4fa320ca5be465f6116a050-
heal.journalNameLife Scien
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2009-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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