IR microspectroscopy: potential applications in cervical cancer screening
Φόρτωση...
Ημερομηνία
Συγγραφείς
Walsh, M. J.
German, M. J.
Singh, M.
Pollock, H. M.
Hammiche, A.
Kyrgiou, M.
Stringfellow, H. F.
Paraskevaidis, E.
Martin-Hirsch, P. L.
Martin, F. L.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Cancer Lett
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Screening exfoliative cytology for early dysplastic cells reduces incidence and mortality from squamous carcinoma of the cervix. In the developed world, screening programmes have adopted a 3-5 years recall system. In its absence, cervical cancer would be the second most common female cancer in these regions; instead, it is currently eleventh. However, there exist a number of limitations to the smear test even given the removal of contaminants using liquid-based cytology. It is prohibitively expensive, labour-intensive and subject to inaccuracies that give rise to significant numbers of false negatives. There remains a need for novel approaches to allow efficient and objective interrogation of exfoliative cytology. Methods that variously exploit infrared (IR) microspectroscopy are one possibility. Using IR microspectroscopy, an integrated 'biochemical-cell fingerprint' of the lipid, protein and carbohydrate composition of a biomolecular entity may be derived in the form of a spectrum via vibrational transitions of individual chemical bonds. Powerful statistical approaches (e.g. principal component analysis) now facilitate the interrogation of large amounts of spectroscopic data to allow the extraction of what may be small but extremely significant biomarker differences between disease-free and pre-malignant or malignant samples. An increasing wealth of literature points to the ability of IR microspectroscopy to allow the segregation of cells based on their disease status. We review the current evidence supporting its diagnostic potential in cancer biology.
Περιγραφή
Λέξεις-κλειδιά
Female, Humans, Mass Screening/instrumentation/methods, Reproducibility of Results, Sensitivity and Specificity, Spectrophotometry, Infrared/*methods, Spectroscopy, Fourier Transform Infrared/methods, Uterine Cervical Neoplasms/*diagnosis
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/16713674
http://ac.els-cdn.com/S0304383506001765/1-s2.0-S0304383506001765-main.pdf?_tid=f41d748c969fb55c68f380f3897884f2&acdnat=1333714128_d4c758faf68a0e7a320e60aa3eb8c156
http://ac.els-cdn.com/S0304383506001765/1-s2.0-S0304383506001765-main.pdf?_tid=f41d748c969fb55c68f380f3897884f2&acdnat=1333714128_d4c758faf68a0e7a320e60aa3eb8c156
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής