Comparison of monotherapy versus combination antihypertensive therapy in elderly patients with essential hypertension

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dc.contributor.authorAntonopoulos, S.en
dc.contributor.authorKokkoris, S.en
dc.contributor.authorGerakari, S.en
dc.contributor.authorMikros, S.en
dc.contributor.authorNitsotolis, T.en
dc.contributor.authorVikeli, D.en
dc.contributor.authorKorantzopoulos, P.en
dc.contributor.authorGiannoulis, G.en
dc.date.accessioned2015-11-24T19:28:31Z
dc.date.available2015-11-24T19:28:31Z
dc.identifier.issn0003-3197-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22904
dc.rightsDefault Licence-
dc.subjectAcrylates/administration & dosageen
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectAmlodipine/administration & dosageen
dc.subjectAntihypertensive Agents/*administration & dosageen
dc.subjectDiastole/drug effectsen
dc.subjectDose-Response Relationship, Drugen
dc.subjectDrug Therapy, Combinationen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectHypertension/*drug therapyen
dc.subjectImidazoles/administration & dosageen
dc.subjectImidazolidines/administration & dosageen
dc.subjectIndapamide/administration & dosageen
dc.subjectMaleen
dc.subjectSystole/drug effectsen
dc.subjectThiophenes/administration & dosageen
dc.subjectTreatment Outcomeen
dc.titleComparison of monotherapy versus combination antihypertensive therapy in elderly patients with essential hypertensionen
heal.abstractAuthors sought to compare the efficacy of monotherapy versus combination antihypertensive therapy in elderly patients. Patients in this study, aged 65 to 85 years, were divided into 4 groups and entered an 8-week treatment period. First group: 22 patients, amlodipine 5 mg/d increasing to 10 mg; second: 20 patients, eprosartan 600 mg/d increasing to 600 mg twice a day; third: 21 patients, amlodipine 5 mg/d and indapamide 2.5 mg/d, increasing amlodipine to 10 mg/d; fourth: 23 patients, imidapril 10 mg/d and indapamide 2.5 mg/d, imidapril doubled to 20 mg/d. A greater drop in systolic and in diastolic blood pressure was obtained by combination of amlodipine and indapamide compared with amlodipine or eprosartan monotherapy. Imidapril and indapamide showed similar efficacy compared with eprosartan monotherapy but not with amlodipine monotherapy. Amlodipine and indapamide appeared more effective than imidapril and indapamide in diastolic blood pressure. Combination treatment with amlodipine and indapamide or imidapril and indapamide effectively reduces blood pressure in elderly patients with essential hypertension.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1177/0003319707304580-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/18388088-
heal.identifier.secondaryhttp://ang.sagepub.com/content/59/2/230.full.pdf-
heal.journalNameAngiologyen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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