Overexpression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo

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dc.contributor.authorFueyo, J.en
dc.contributor.authorGomez-Manzano, C.en
dc.contributor.authorYung, W. K.en
dc.contributor.authorLiu, T. J.en
dc.contributor.authorAlemany, R.en
dc.contributor.authorMcDonnell, T. J.en
dc.contributor.authorShi, X.en
dc.contributor.authorRao, J. S.en
dc.contributor.authorLevin, V. A.en
dc.contributor.authorKyritsis, A. P.en
dc.date.accessioned2015-11-24T19:00:26Z
dc.date.available2015-11-24T19:00:26Z
dc.identifier.issn1078-8956-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19533
dc.rightsDefault Licence-
dc.subjectAdenoviruses, Human/geneticsen
dc.subjectAnimalsen
dc.subjectApoptosis/genetics/*physiologyen
dc.subject*Carrier Proteinsen
dc.subjectCell Cycle Proteins/genetics/physiologyen
dc.subjectCell Death/genetics/physiologyen
dc.subjectCell Survival/genetics/physiologyen
dc.subjectCyclin-Dependent Kinase Inhibitor p16/metabolismen
dc.subjectDNA-Binding Proteins/genetics/physiologyen
dc.subjectDisease Models, Animalen
dc.subjectE2F Transcription Factorsen
dc.subjectE2F1 Transcription Factoren
dc.subjectGene Expression/geneticsen
dc.subjectGene Therapyen
dc.subjectGenes, Tumor Suppressoren
dc.subjectGenetic Vectors/geneticsen
dc.subjectGlioma/*genetics/physiopathology/therapyen
dc.subjectHumansen
dc.subjectMiceen
dc.subjectMice, Inbred BALB Cen
dc.subjectMice, Nudeen
dc.subjectOncogene Protein p21(ras)/metabolismen
dc.subjectRecombinant Fusion Proteins/geneticsen
dc.subjectRetinoblastoma Protein/metabolismen
dc.subjectRetinoblastoma-Binding Protein 1en
dc.subjectTranscription Factor DP1en
dc.subjectTranscription Factors/*genetics/physiologyen
dc.subjectTransfection/geneticsen
dc.subjectTumor Cells, Cultureden
dc.titleOverexpression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivoen
heal.abstractThe transfer of apoptosis genes to tumors is one of the most promising strategies for cancer gene therapy. We have shown that massive apoptosis occurs when wild-type p53 expression is induced in glioma cells carrying a p53 gene mutation. However, adenovirus-mediated p53 gene transfer is ineffective in causing apoptosis in glioma cells that retain a wild-type p53 genotype. We evaluated the effect of E2F-1 overexpression on the growth of gliomas in vitro and in vivo. In the in vitro study, the adenovirus-mediated transfer of exogenous E2F-1 protein precipitated generalized apoptosis in gliomas. The treatment with Ad5CMV-E2F-1 of nude mice carrying subcutaneous gliomas arrested tumor growth. Our results indicate that E2F-1 has anti-glioma activity in vitro and in vivo.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/9623977-
heal.journalNameNat Meden
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1998-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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