N-Acetylcysteine ameliorates the late phase of liver ischaemia/reperfusion injury in the rabbit with hepatic steatosis

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dc.contributor.authorFusai, G.en
dc.contributor.authorGlantzounis, G. K.en
dc.contributor.authorHafez, T.en
dc.contributor.authorYang, W.en
dc.contributor.authorQuaglia, A.en
dc.contributor.authorSheth, H.en
dc.contributor.authorKanoria, S.en
dc.contributor.authorParkes, H.en
dc.contributor.authorSeifalian, A.en
dc.contributor.authorDavidson, B. R.en
dc.date.accessioned2015-11-24T19:02:41Z
dc.date.available2015-11-24T19:02:41Z
dc.identifier.issn0143-5221-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19825
dc.rightsDefault Licence-
dc.subjectAcetylcysteine/*therapeutic useen
dc.subjectAlanine Transaminase/metabolismen
dc.subjectAnimalsen
dc.subjectBile/secretionen
dc.subjectCholesterol, Dietary/administration & dosageen
dc.subjectFatty Liver/*complications/etiology/pathologyen
dc.subjectHemodynamics/drug effectsen
dc.subjectLiver/physiopathologyen
dc.subjectLiver Circulation/drug effectsen
dc.subjectMagnetic Resonance Spectroscopyen
dc.subjectMicrocirculation/drug effectsen
dc.subjectOxidation-Reduction/drug effectsen
dc.subjectOxidative Stress/drug effectsen
dc.subjectRabbitsen
dc.subjectReperfusion Injury/etiology/*prevention & controlen
dc.titleN-Acetylcysteine ameliorates the late phase of liver ischaemia/reperfusion injury in the rabbit with hepatic steatosisen
heal.abstractSteatotic livers are highly susceptible to I/R (ischaemia/reperfusion) injury and, therefore, the aim of the present study was to evaluate the in vivo effect of NAC (N-acetylcysteine) on hepatic function in the early and initial late phase of warm liver I/R injury in steatotic rabbits. Twelve New Zealand White rabbits were fed a high-cholesterol (2%) diet. The control group (n=6) underwent lobar liver ischaemia for 1 h, followed by 6 h of reperfusion. In the treated group receiving NAC (n=6), an intravenous infusion of NAC was administered prior to and during the 6 h reperfusion period. Systemic and hepatic haemodynamics were monitored continuously. ALT (alanine aminotransferase) activity and bile production were measured. NMR spectroscopy was used to analyse bile composition. Oxidation of DHR (dihydrorhodamine) to RH (rhodamine) was used as a marker of production of reactive oxygen and nitrogen species. Moderate centrilobular hepatic steatosis was demonstrated by histology. The results showed that NAC administration significantly improved portal flow, hepatic microcirculation, bile composition and bile flow after 5 h of reperfusion. NAC administration was also associated with less hepatocellular injury, as indicated by ALT serum activity, and decreased the oxidation of DHR to RH. In conclusion, NAC administration decreased the extent of I/R injury in the steatotic liver, particularly during the late phase of reperfusion.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1042/CS20050081-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15982189-
heal.journalNameClin Sci (Lond)en
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2005-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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