Long-term prognostic value of baseline C-reactive protein in predicting recurrence of atrial fibrillation after electrical cardioversion
Φόρτωση...
Ημερομηνία
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Pacing Clin Electrophysiol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND: An increasing body of evidence links atrial fibrillation (AF) to the inflammatory state. It has been suggested that increased C-reactive protein (CRP) levels are associated with greater risk of AF recurrence at short- and mid-term. OBJECTIVE: We sought to investigate the association between CRP and long-term risk of AF recurrence. METHODS: This was a prospective observational study. We investigated the association between baseline CRP levels and recurrence of AF over a 3-year follow-up period after successful electrical cardioversion (EC). A total of 60 patients were studied (mean age: 68.4 +/- 7.2 years, 60% men). All patients were receiving amiodarone for sinus rhythm maintenance. We further divided the study population into three tertiles according to the values of baseline CRP (tertile 1: <0.43 mg/dL; tertile 2: 0.43-0.8 mg/dL; tertile 3: >0.8 mg/dL). RESULTS: Overall, 75% of patients relapsed into AF during the 3-year study period. AF recurrence was significantly lower in the 1st CRP tertile group (P = 0.039). The Kaplan-Meier survival analysis showed that the rate of AF recurrence was significantly lower in the lowest CRP tertile (log rank; P < 0.001). In a multivariable Cox regression model adjusted for other potential covariates, only CRP (upper two tertiles) was an independent predictor of AF recurrence (heart rate: 6.3, 95% confidence interval: 3.1-12.7, P < 0.001). CONCLUSIONS: Our findings suggest that baseline CRP levels before EC have an independent prognostic value in predicting the long-term risk of AF recurrence.
Περιγραφή
Λέξεις-κλειδιά
*Atrial Fibrillation/blood/diagnosis/mortality/prevention & control, C-Reactive Protein/*analysis, Electric Countershock/*mortality, Female, Greece/epidemiology, Humans, Longitudinal Studies, Male, Prevalence, Prognosis, Reproducibility of Results, Sensitivity and Specificity, Survival Analysis, Survival Rate, Treatment Outcome
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/18811807
http://onlinelibrary.wiley.com/store/10.1111/j.1540-8159.2008.01177.x/asset/j.1540-8159.2008.01177.x.pdf?v=1&t=h0tb6xkl&s=6bc87580cbcd3bc04268a0302b3ef6480df6bea4
http://onlinelibrary.wiley.com/store/10.1111/j.1540-8159.2008.01177.x/asset/j.1540-8159.2008.01177.x.pdf?v=1&t=h0tb6xkl&s=6bc87580cbcd3bc04268a0302b3ef6480df6bea4
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής