Oxidative stress is progressively enhanced with advancing stages of CKD

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dc.contributor.authorDounousi, E.en
dc.contributor.authorPapavasiliou, E.en
dc.contributor.authorMakedou, A.en
dc.contributor.authorIoannou, K.en
dc.contributor.authorKatopodis, K. P.en
dc.contributor.authorTselepis, A.en
dc.contributor.authorSiamopoulos, K. C.en
dc.contributor.authorTsakiris, D.en
dc.date.accessioned2015-11-24T19:00:21Z
dc.date.available2015-11-24T19:00:21Z
dc.identifier.issn1523-6838-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19516
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectCross-Sectional Studiesen
dc.subjectDinoprost/analogs & derivatives/blooden
dc.subjectDisease Progressionen
dc.subjectFemaleen
dc.subjectGlomerular Filtration Rateen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subject*Oxidative Stress/physiologyen
dc.subjectRegression Analysisen
dc.subjectRenal Insufficiency, Chronic/*metabolismen
dc.subjectUric Acid/blooden
dc.titleOxidative stress is progressively enhanced with advancing stages of CKDen
heal.abstractBACKGROUND: Oxidative stress appears to have a central role in the pathophysiological process of uremia and its complications, including cardiovascular disease. However, there is little evidence to suggest how early oxidative stress starts developing during the progression of chronic kidney disease (CKD). The aim of this study is to assess oxidative stress activity in a cross-sectional study of patients with CKD stages 1 to 4. METHODS: Eighty-seven steady patients (47 men, 40 women) with a median age of 62 years (range, 28 to 84 years) and mean estimated glomerular filtration rate (eGFR) of 57 mL/min (0.95 mL/s) were studied. Levels of plasma 8-isoprostanes (8-epiPGF2a) and serum total antioxidant status (TAS) were used as markers of oxidative stress. 8-epiPGF2a levels were determined by using an enzyme-linked immunosorbent assay method, whereas a chromatometric method was used to determine TAS. RESULTS: Plasma 8-epiPGF2a levels increased significantly as CKD stages advanced (P < 0.001). There was a highly significant inverse correlation between 8-epiPGF2a level and GFR (P < 0.01). Serum TAS levels also increased in a similar fashion (P < 0.009) and showed a significant inverse correlation with GFR (P < 0.01). 8-epiPGF2a and TAS levels showed a positive correlation (P < 0.05). Multiple regression analysis showed that the most significant predictor variable for 8-epiPGF2a level was eGFR, whereas the association between eGFR and TAS was affected strongly by confounding variables, mainly uric acid level. CONCLUSION: Oxidative stress appears to increase as CKD progresses and correlates significantly with level of renal function. Increased TAS seems to be dependent on several confounding variables, including increased uric acid levels, and therefore does not seem to be a reliable method for assessing the antioxidant capacity of patients with CKD. These results suggest that larger studies using the correct markers to assess the timing and complex interplay of oxidative stress and other risk factors during the progression of CKD should be carried out.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1053/j.ajkd.2006.08.015-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17059994-
heal.journalNameAm J Kidney Disen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2006-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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