MRI deterioration in herpes simplex encephalitis despite clinical recovery

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dc.contributor.authorMarkoula, S.en
dc.contributor.authorGiannopoulos, S.en
dc.contributor.authorPelidou, S. H.en
dc.contributor.authorArgyropoulou, M.en
dc.contributor.authorLagos, G.en
dc.contributor.authorKyritsis, A. P.en
dc.date.accessioned2015-11-24T19:03:29Z
dc.date.available2015-11-24T19:03:29Z
dc.identifier.issn1074-7931-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19905
dc.rightsDefault Licence-
dc.subjectAcyclovir/therapeutic useen
dc.subjectAnticonvulsants/therapeutic useen
dc.subjectAntiviral Agents/therapeutic useen
dc.subjectBrain/*pathology/radiography/*virologyen
dc.subjectCerebral Cortex/pathologyen
dc.subjectChronic Disease/drug therapyen
dc.subjectDisease Progressionen
dc.subjectEncephalitis, Herpes Simplex/immunology/*pathology/physiopathologyen
dc.subjectFemaleen
dc.subjectFrontal Lobe/pathologyen
dc.subjectGyrus Cinguli/pathologyen
dc.subjectHumansen
dc.subjectMagnetic Resonance Imagingen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNerve Fibers, Myelinated/pathologyen
dc.subjectRecovery of Function/immunologyen
dc.subjectRecurrenceen
dc.subjectRetrospective Studiesen
dc.subjectTemporal Lobe/pathologyen
dc.subjectTomography, X-Ray Computeden
dc.subjectTreatment Outcomeen
dc.titleMRI deterioration in herpes simplex encephalitis despite clinical recoveryen
heal.abstractOBJECTIVES: Herpes simplex virus type 1 is a sporadic cause of viral encephalitis. Relapse of encephalitis occurs in up to 10% of patients, manifested by recurrent symptoms, clinical and MRI findings, and the presence of herpes simplex virus type 1 DNA in the cerebrospinal fluid (CSF). METHODS: We describe the clinical features, MRI findings and outcome in 2 patients with herpes simplex encephalitis during the acute phase and 6 months after the onset of encephalitis. RESULTS: Both patients had a good response to treatment and an excellent recovery. Despite clinical recovery, in a 6-month follow-up MRI lesions consistent with recurrence were disclosed, without any clinical findings or CSF abnormalities. CONCLUSIONS: The mechanism underlying this MRI deterioration is unclear and an immune-mediated mechanism may be involved. Thus, MRI deterioration after herpes simplex encephalitis should be interpreted with caution and it does not always represent a relapse, especially when the imaging studies do not correlate with the clinical and CSF findings.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1097/NRL.0b013e3181921abc-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19590384-
heal.journalNameNeurologisten
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2009-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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