A mathematical model of blood, cerebrospinal fluid and brain dynamics

Απλή σελίδα τεκμηρίου
dc.contributor.authorLinninger, A. A.en
dc.contributor.authorXenos, M.en
dc.contributor.authorSweetman, B.en
dc.contributor.authorPonkshe, S.en
dc.contributor.authorGuo, X. D.en
dc.contributor.authorPenn, R.en
dc.date.accessioned2015-11-24T17:24:26Z
dc.date.available2015-11-24T17:24:26Z
dc.identifier.issn0303-6812-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/12895
dc.rightsDefault Licence-
dc.subjectcerebrospinal fluiden
dc.subjectcommunicating hydrocephalusen
dc.subjectintracranial pressureen
dc.subjectmathematical modelingen
dc.subjectcomputational fluid dynamicsen
dc.subjectintracranial-pressure dynamicsen
dc.subjectcerebrovascular systemen
dc.subjecthydrocephalus shuntsen
dc.subjectmagnetic-resonanceen
dc.subjectflowen
dc.subjectconsolidationen
dc.subjecthemodynamicsen
dc.subjectcirculationen
dc.subjecttransporten
dc.subjectdiseaseen
dc.titleA mathematical model of blood, cerebrospinal fluid and brain dynamicsen
heal.abstractUsing first principles of fluid and solid mechanics a comprehensive model of human intracranial dynamics is proposed. Blood, cerebrospinal fluid (CSF) and brain parenchyma as well as the spinal canal are included. The compartmental model predicts intracranial pressure gradients, blood and CSF flows and displacements in normal and pathological conditions like communicating hydrocephalus. The system of differential equations of first principles conservation balances is discretized and solved numerically. Fluid-solid interactions of the brain parenchyma with cerebral blood and CSF are calculated. The model provides the transitions from normal dynamics to the diseased state during the onset of communicating hydrocephalus. Predicted results were compared with physiological data from Cine phase-contrast magnetic resonance imaging to verify the dynamic model. Bolus injections into the CSF are simulated in the model and found to agree with clinical measurements.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1007/s00285-009-0250-2-
heal.identifier.secondary<Go to ISI>://000269208900001-
heal.identifier.secondaryhttp://www.springerlink.com/content/dpu527222284265k/fulltext.pdf-
heal.journalNameJournal of Mathematical Biologyen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2009-
heal.publisherSpringer Verlag (Germany)en
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Μαθηματικώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΜΑΘ