The clinical significance of soluble E-cadherin in nonsmall cell lung cancer

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dc.contributor.authorCharalabopoulos, K.en
dc.contributor.authorGogali, A.en
dc.contributor.authorDalavaga, Y.en
dc.contributor.authorDaskalopoulos, G.en
dc.contributor.authorVassiliou, M.en
dc.contributor.authorBablekos, G.en
dc.contributor.authorKarakosta, A.en
dc.contributor.authorConstantopoulos, S.en
dc.date.accessioned2015-11-24T19:42:17Z
dc.date.available2015-11-24T19:42:17Z
dc.identifier.issn1812-9269-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24617
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectCadherins/*blooden
dc.subjectCarcinoma, Non-Small-Cell Lung/*pathologyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectLung Neoplasms/*pathologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPrognosisen
dc.subjectSmokingen
dc.subjectTumor Markers, Biological/blooden
dc.titleThe clinical significance of soluble E-cadherin in nonsmall cell lung canceren
heal.abstractAIM: Aberrant expression of the epithelial transmembrane adhesion molecule E-cadherin (E-cad) has been associated with many human malignancies. In the present study the clinical significance of serum levels of soluble E-cadherin (sE-cad) in newly diagnosed patients with non small cell lung cancer (NSCLC) was investigated. MATERIAL AND METHODS: An enzyme linked immunospecific assay (ELISA) to determine the circulating levels of sE-cad in 20 newly diagnosed patients with NSCLC as well as in 29 healthy volunteers (control group) was used. RESULTS: NSCLC patients exerted increased circulating levels of sE-cad compared with individuals of the control group (p < 0.001). An association was also detected between serum sE-cad levels and the development of distant metastases. On the contrary, no statistically significant correlation could be established with histological type, gender and smoking habits. Patients with increased sE-cad levels at diagnosis had worser outcome, although multivariate analysis failed to demonstrate that sE-cad levels represent an independent prognostic factor of survival. CONCLUSION: Our data suggest that E-cad plays a role in the pathogenesis of NSCLC. sE-cad levels may be further studied as a potential prognostic biomarker.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16614715-
heal.journalNameExp Oncolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2006-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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