Cytotoxic activity and antiproliferative effects of a new semi-synthetic derivative of Ent-3 beta-hydroxy-13-epi-manoyl oxide on human leukemic cell lines

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dc.contributor.authorDimas, K.en
dc.contributor.authorDemetzos, C.en
dc.contributor.authorMitaku, S.en
dc.contributor.authorVaos, B.en
dc.contributor.authorMarselos, M.en
dc.contributor.authorTzavaras, T.en
dc.contributor.authorKokkinopoulos, D.en
dc.date.accessioned2015-11-24T19:25:31Z
dc.date.available2015-11-24T19:25:31Z
dc.identifier.issn0250-7005-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22631
dc.rightsDefault Licence-
dc.subjectAntineoplastic Agents, Phytogenic/pharmacologyen
dc.subjectCell Cycle/drug effectsen
dc.subjectCell Division/drug effectsen
dc.subjectDNA Damageen
dc.subjectDimethyl Sulfoxide/pharmacologyen
dc.subjectDiterpenes/*chemistry/*pharmacologyen
dc.subjectDose-Response Relationship, Drugen
dc.subjectEtoposide/pharmacologyen
dc.subjectFlow Cytometryen
dc.subjectHL-60 Cellsen
dc.subjectHumansen
dc.subjectInhibitory Concentration 50en
dc.subjectLeukemia/*pathologyen
dc.subjectSolvents/pharmacologyen
dc.subjectTime Factorsen
dc.subjectTumor Cells, Cultureden
dc.titleCytotoxic activity and antiproliferative effects of a new semi-synthetic derivative of Ent-3 beta-hydroxy-13-epi-manoyl oxide on human leukemic cell linesen
heal.abstractEnt-3 beta-hydroxy-13-epi-manoyl oxide (1), was converted to its thiomidazolide derivative (2) which was tested for its cytotoxic activity against a panel of established human leukemic cell lines. Compound 2, exhibited cytotoxic activity against 13 of the cell lines tested. Additionally, compound 2 was examined for its effect on the uptake of [3H]-thymidine as a marker of DNA synthesis and on cell proliferation. The morphology of the cells and the kind of death induced, was investigated. Flow cytometry experiments on a leukemic cell line was also performed. The results show that the semi-synthetic compound, showed a significant antiproliferative effect and kills cells through the process of apoptosis. The appearance of the apoptotic signs was time and dose dependent. From the flow cytometry experiments, a synchronisation through a delay of the cells in G0/1, phase seems to take place.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/10628355-
heal.journalNameAnticancer Resen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1999-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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