Synthesis, characterization and biological studies of new antimony(III) halide complexes with Ο‰-thiocaprolactam
| dc.contributor.author | Ozturk, I. I. | en |
| dc.contributor.author | Banti, C. N. | en |
| dc.contributor.author | Manos, M. J. | en |
| dc.contributor.author | Tasiopoulos, A. J. | en |
| dc.contributor.author | Kourkoumelis, N. | en |
| dc.contributor.author | Charalabopoulos, K. | en |
| dc.contributor.author | Hadjikakou, S. K. | en |
| dc.date.accessioned | 2015-11-24T16:49:25Z | |
| dc.date.available | 2015-11-24T16:49:25Z | |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/9482 | |
| dc.rights | Default Licence | - |
| dc.subject | Bioinorganic chemistry | en |
| dc.subject | Antimony(III) halide complexes | en |
| dc.subject | Ο‰-Thiocaprolactam | en |
| dc.subject | Crystal structures | en |
| dc.subject | Cytotoxic activity | en |
| dc.title | Synthesis, characterization and biological studies of new antimony(III) halide complexes with Ο‰-thiocaprolactam | en |
| heal.abstract | Three new antimony(III) halide complexes (SbX3, X = Cl, Br and I) with the heterocyclic thione Ο‰-thiocaprolactam (1-azacycloheptane-2-thione, (Hthcl)) of formulae {[SbCl2(ΞΌ2-Cl)(Hthcl)2]n} (1), {[(SbBr2(ΞΌ2-Br)(Hthcl)2)2]} (2) and {[(SbI2(ΞΌ2-I)(Hthcl)2)2]} (3) were synthesized from the reaction of antimony(III) halides with Ο‰-thiocaprolactam in 1:2 stoichiometry. The complexes were characterized by elemental analysis, FT-IR spectroscopy, 1H, 13C NMR spectroscopy and Thermal Gravimetry-Differential Thermal Analysis (TG-DTA). Crystal structures of the ligand Ο‰-thiocaprolactam and its complexes 1-3 were determined with single crystal X-ray diffraction analysis. Complexes 1-3 and Ο‰-thiocaprolactam were evaluated for their in vitro cytotoxic activity against leiomyosarcoma (LMS) and human breast adenocarcinoma (MCF-7) tumor cell lines. Antimony complexes 1-3 exhibit strong antiproliferative activity against both cell lines tested. The higher such activity was found for 3 with IC50 values of 0.12 Β± 0.04 ΞΌM (LMS) and 0.76 Β± 0.16 ΞΌM (MCF-7) which are 60 and 10 times respectively, stronger than that of cisplatin. The influence of these complexes 1-3 and Ο‰-thiocaprolactam upon the catalytic peroxidation of linoleic acid to hyperoxolinoleic acid by the enzyme lipoxygenase (LOX) was kinetically and theoretically studied. The results were shown negligible inhibitory activity of 1-3 against LOX. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1016/j.jinorgbio.2012.01.014 | - |
| heal.identifier.secondary | http://www.sciencedirect.com/science/article/pii/S0162013412000414 | - |
| heal.journalName | J. Inorg Biochem. | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2012 | - |
| heal.publisher | Elsevier | en |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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