Treatment and retreatment in patients with chronic hepatitis C: 10 years clinical practice in a single centre
Φόρτωση...
Ημερομηνία
Συγγραφείς
Economou, M. S.
Filis, S.
Vienna, H.
Christodoulou, D.
Christou, L.
Tsianos, E. V.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Liver Int
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
AIM: Therapy for chronic hepatitis C (HCV) has mainly been evaluated in large clinical, select population, trials. We sought to evaluate whether prognostic factors of therapeutic response are similar in clinical practice, where treated population is more diverse. METHODS: Retrospective study of HCV-infected patients who completed >6 months of treatment/retreatment with various therapeutic regimens, in a single reference centre over a 10-year period. Adjuvant treatment with hemopoetic growth factors was used when warranted by treatment side effects. RESULTS: Overall, 77/125 patients (61.6%) achieved sustained virological response (SVR). Fifty-four naive patients (43.2%) achieved SVR; 19 (26%) with interferon-alpha (IFN-alpha), 13 (59.1%) with IFN-alpha and ribavirin, and 22 (73.3%) with pegylated IFN-alpha and ribavirin. Seventeen patients responded after two courses of therapy and six after more than three courses, achieving a total SVR of 32%. Patients with genotype-1 were less probable to achieve SVR [odds ratio (OR)=6.23], while younger patients were more possible to achieve SVR, OR=0.97. Most non-responders after >2 regimens were genotype-1 patients (90%). CONCLUSIONS: In clinical practice, where strict selection criteria cannot be applied, genotype-1 remains the most significant prognostic factor of response failure. Addition of adjuvant hemopoetic growth factors, when warranted, may increase compliance and thus overall SVR.
Περιγραφή
Λέξεις-κλειδιά
Adult, Antiviral Agents/adverse effects/*therapeutic use, Female, Hepatitis C, Chronic/*drug therapy/virology, Humans, Interferon-alpha/adverse effects/therapeutic use, Male, Middle Aged, Polyethylene Glycols/adverse effects/therapeutic use, Recombinant Proteins, Retreatment, Ribavirin/adverse effects/therapeutic use
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/17355455
http://onlinelibrary.wiley.com/store/10.1111/j.1478-3231.2006.01437.x/asset/j.1478-3231.2006.01437.x.pdf?v=1&t=h0t9j2w0&s=97b1362a24ddb8f049cede9156a2dc0b7424d52d
http://onlinelibrary.wiley.com/store/10.1111/j.1478-3231.2006.01437.x/asset/j.1478-3231.2006.01437.x.pdf?v=1&t=h0t9j2w0&s=97b1362a24ddb8f049cede9156a2dc0b7424d52d
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής