Radical therapy for muscle-infiltrating bladder cancer (cystectomy or radiotherapy): does age affect the final therapeutic benefit for the patient?
Φόρτωση...
Ημερομηνία
Συγγραφείς
Kalogeras, D.
Lampri, E.
Goussia, A.
Bai, M.
Capizzello, A.
Tassiou, I.
Stavropoulos, N. E.
Tsekeris, P.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Journal of Buon
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Purpose: To evaluate the therapeutic outcome of radical cystectomy and radical radio therapy in patients with T2N0M0 clinical stage bladder cancer in relation to their age. Patients and methods: Between 1995-2006, 119 patients with clinical stage T2N0M0 bladder cancer were treated with radical radiotherapy (group A) and were divided in 2 subgroups: > 70 years old(A1) and <= 70 years old (A2). Between 1998-2006, 26 patients with the same clinical stage were treated with radical cystectomy (group B) (> 70 years old/B1 subgroup and <= 70 years old/B2 subgroup). The following parameters were evaluated in both groups and subgroups: therapeutic outcome (overall survival/OS, local control, development of metastases) and tolerance (side effects and complications of each method). Kaplan-Meier method and log-rank test were used for statistical analyses. Results: All group B patients tolerated their treatment very well, without interruptions. The 3-year OS of groups A and B was 39 and 69%, respectively (p= 0.032). The 3-year OS of subgroups A I and A 2 was 37.3 and 43.3%, respectively (p= 0.085). In the cystectomy group B, 3-year OS of the subgroups was the same (B1: 68.6% and B2: 69.3%; p= 0.10). Local control rate for the subgroups A1, A2, B1, B2 was 43, 40, 90 and 84%, respectively. Distant metastatic rate was 14.1, 20, 7.6 and 7.4% for subgroups A1, A2, B1, B2, respectively. Conclusion: The results of both therapeutic methods in both age groups seem satisfactory. Very good tolerance was also observed. It seems that if a patient is not completely suitable for radical cystectomy or radical radiotherapy age should not be considered as an exclusion factor.
Περιγραφή
Λέξεις-κλειδιά
age, bladder cancer, cystectomy, muscle-infiltrating, radiotherapy, survival, transitional-cell carcinoma, ileal conduit diversion, term-follow-up, neoadjuvant chemotherapy, survival, preservation, complications, metastases, radiation, prostate
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000259689200006
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών