Proteome Analysis of Bronchoalveolar Lavage in Individuals from Metsovo, Nonoccupationally Exposed to Asbestos

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dc.contributor.authorArchimandriti, D. T.en
dc.contributor.authorDalavanga, Y. A.en
dc.contributor.authorCianti, R.en
dc.contributor.authorBianchi, L.en
dc.contributor.authorManda-Stachouli, C.en
dc.contributor.authorArmini, A.en
dc.contributor.authorKoukkou, A. I. I.en
dc.contributor.authorRottoli, P.en
dc.contributor.authorConstantopoulos, S. H.en
dc.contributor.authorBini, L.en
dc.date.accessioned2015-11-24T16:45:42Z
dc.date.available2015-11-24T16:45:42Z
dc.identifier.issn1535-3893-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/8971
dc.rightsDefault Licence-
dc.subjectmetsovo lungen
dc.subjectasbestosen
dc.subjecttremoliteen
dc.subjectmalignant mesotheliomaen
dc.subjectpleural calcificationsen
dc.subjectbronchoalveolar lavageen
dc.subjectproteomicsen
dc.subjecttwo-dimensional electrophoresisen
dc.subjectacid ceramidaseen
dc.subjectglutathione-s-transferaseen
dc.subjectmalignant pleural mesotheliomaen
dc.subjectbovine serum-albuminen
dc.subjectfree-radicalsen
dc.subjectacid ceramidaseen
dc.subjectlung-canceren
dc.subjectcell-deathen
dc.subject2-dimensional electrophoresisen
dc.subjecthsp27 oligomerizationen
dc.subjectca2+-binding proteinen
dc.titleProteome Analysis of Bronchoalveolar Lavage in Individuals from Metsovo, Nonoccupationally Exposed to Asbestosen
heal.abstractInhabitants of Metsovo, NW Greece, have been exposed to an asbestos whitewash, resulting in malignant pleural mesothelioma (MPM) and pleural calcifications (PCs). Interestingly, those with PCs (PC(+)) are less prone to MPM. They also have lymphocytic alveolitis, and differences in bronchoalveolar lavage (BAL) proteins, compared with those without pleural calcifications (PC(-)). This may mean a different response to the fiber leading to different susceptibility to neoplasia. To further evaluate this, a proteomic analysis of BAL proteins was performed. Proteomic analysis (2D-electrophoresis/Mass Spectrometry) of BAL in Metsovites nonoccupationally exposed to asbestos revealed increased albumin fragments, alpha 1-antitrypsin, S100-A9 and HSP27, suggesting ongoing inflammation. In those without pleural calcifications, increased expression of acid ceramidase, glutathione-S-transferase and presence of calcyphosin, all involved in cell cycle regulation and death as well as in the detoxification of mutagenic and toxic agents, lend further support to our thesis of possible "protection against neoplasia" in Metsovites with pleural calcifications.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDoi 10.1021/Pr800370n-
heal.identifier.secondary<Go to ISI>://000263193300046-
heal.identifier.secondaryhttp://pubs.acs.org/doi/abs/10.1021/pr800370n-
heal.journalNameJ Proteome Resen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2009-
heal.publisherAmerican Chemical Societyen
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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