Mycosis fungoides: expression of C-myc p62 p53, bcl-2 and PCNA proteins and absence of association with Epstein-Barr virus

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dc.contributor.authorKanavaros, P.en
dc.contributor.authorIoannidou, D.en
dc.contributor.authorTzardi, M.en
dc.contributor.authorDatseris, G.en
dc.contributor.authorKatsantonis, J.en
dc.contributor.authorDelidis, G.en
dc.contributor.authorTosca, A.en
dc.date.accessioned2015-11-24T19:02:49Z
dc.date.available2015-11-24T19:02:49Z
dc.identifier.issn0344-0338-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19838
dc.rightsDefault Licence-
dc.subjectHerpesvirus 4, Human/*isolation & purificationen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectIn Situ Hybridizationen
dc.subjectMycosis Fungoides/*chemistry/*virologyen
dc.subjectProliferating Cell Nuclear Antigen/biosynthesisen
dc.subjectProto-Oncogene Proteins/biosynthesisen
dc.subjectProto-Oncogene Proteins c-bcl-2en
dc.subjectProto-Oncogene Proteins c-myc/biosynthesisen
dc.subjectSkin Neoplasms/*chemistry/*virologyen
dc.subjectTumor Suppressor Protein p53/biosynthesisen
dc.titleMycosis fungoides: expression of C-myc p62 p53, bcl-2 and PCNA proteins and absence of association with Epstein-Barr virusen
heal.abstractThe expression of C-myc p62, bcl-2, p53, PCNA and EBV-encoded LMP-1 proteins was studied by immunohistochemistry on paraffin-embedded skin specimens from 14 patients with early stage (premycotic erythema and second stage plaques) mycosis fungoides (MF), 21 patients with advanced stage MF (third stage plaques and tumors), 3 patients with Sezary's syndrome (SS) and 3 patients with pleomorphic medium and large cell cutaneous T-cell lymphomas (PML-CTCL). All 41 cases were also screened for the presence of EBV by using RNA in situ hybridization with EBER 1/2 oligonucleotides. Increased expression of C-myc p62, p53 and PCNA proteins was found in PML-CTCL and advanced stages of MF as compared to early stages of MF. These results suggest a relationship between levels of C-myc p62, p53 and PCNA proteins and aggressiveness of the cutaneous T-cell lymphomas. Furthermore, C-myc p62 and bcl-2 proteins were found to be frequently coexpressed in the present series. In view of the background information from in vitro findings and animal models that cooperation of C-myc and bcl-2 is important for lymphomagenesis, our results suggest that coexpression of these oncogenes may be implicated in the pathogenesis and/or the progression of cutaneous T-cell lymphomas. Neither LMP-1 expression nor EBV EBER l/2 transcripts were detected in our series suggesting that EBV is not involved in the pathogenesis of cutaneous T-cell lymphomas.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/7831152-
heal.journalNamePathol Res Practen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1994-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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