Conditional up-regulation of IL-2 production by p38 MAPK inactivation is mediated by increased Erk1/2 activity
| dc.contributor.author | Kogkopoulou, O. | en |
| dc.contributor.author | Tzakos, E. | en |
| dc.contributor.author | Mavrothalassitis, G. | en |
| dc.contributor.author | Baldari, C. T. | en |
| dc.contributor.author | Paliogianni, F. | en |
| dc.contributor.author | Young, H. A. | en |
| dc.contributor.author | Thyphronitis, G. | en |
| dc.date.accessioned | 2015-11-24T16:33:44Z | |
| dc.date.available | 2015-11-24T16:33:44Z | |
| dc.identifier.issn | 0741-5400 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/7701 | |
| dc.rights | Default Licence | - |
| dc.subject | t lymphocytes | en |
| dc.subject | protein kinases | en |
| dc.subject | transcription factors | en |
| dc.subject | signal transduction | en |
| dc.subject | activated protein-kinase | en |
| dc.subject | t-cell-activation | en |
| dc.subject | signal-transduction pathways | en |
| dc.subject | nuclear factor | en |
| dc.subject | inhibition | en |
| dc.subject | expression | en |
| dc.subject | transcription | en |
| dc.subject | stimulation | en |
| dc.subject | differentiation | en |
| dc.subject | components | en |
| dc.title | Conditional up-regulation of IL-2 production by p38 MAPK inactivation is mediated by increased Erk1/2 activity | en |
| heal.abstract | The p38 mitogen-activated protein kinase regulates many cellular processes in almost all eukaryotic cell types. In T cells, p38 was shown to regulate thymic development and cytokine production. Here, the role of p38 on interleukin-2 (IL-2) production by human peripheral blood CD4(+) T cells was examined. When T cells were stimulated under weak stimulation conditions, pharmaceutical and molecular p38 inhibitors induced a dramatic increase of IL-2 production. In contrast, IL-2 levels were not affected significantly when strong stimulation was provided to T cells. The increase in IL-2 production, following p38 inhibition, was associated with a strong up-regulation of extracellular signal-regulated kinase (Erk)1/2 activity. Furthermore the Erk inhibitor U0126 was able to counteract the effect of p38 inhibition on IL-2 production, supporting the conclusion that p38 mediates its effect through Erk. These results suggest that the p38 kinase, through its ability to control Erk activation levels, acts as a gatekeeper, which prevents inappropriate IL-2 production. Also, the finding that p38 acts in a strength-of-stimulation-dependent way provides an explanation for previously reported, contradictory results regarding the role of this kinase in IL-2 expression. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | Doi 10.1189/Jlb.0705418 | - |
| heal.identifier.secondary | <Go to ISI>://000243015200020 | - |
| heal.identifier.secondary | http://www.jleukbio.org/content/79/5/1052.full.pdf | - |
| heal.journalName | J Leukoc Biol | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2006 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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