Effects of Ascorbic-Acid on Tert-Butyl Hydroperoxide-Induced Deformability Decrease in Human Erythrocytes

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dc.contributor.authorGalaris, D.en
dc.contributor.authorYova, D.en
dc.contributor.authorKorantzopoulos, P.en
dc.contributor.authorBarbounaki, S.en
dc.contributor.authorKoutsouris, D.en
dc.date.accessioned2015-11-24T19:21:49Z
dc.date.available2015-11-24T19:21:49Z
dc.identifier.issn0271-5198-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22124
dc.rightsDefault Licence-
dc.subjectred cell deformabilityen
dc.subjecttert-butyl hydroperoxideen
dc.subjectascorbic aciden
dc.subjecthuman erythrocytesen
dc.subjectcell transit analyzeren
dc.subjectpotential protective mechanismen
dc.subjectsperm whale myoglobinen
dc.subjectlipid-peroxidationen
dc.subjecthemoglobinen
dc.subjectmetmyoglobinen
dc.subjectoxidationen
dc.subjectdamageen
dc.subjectinjuryen
dc.subjectmuscleen
dc.titleEffects of Ascorbic-Acid on Tert-Butyl Hydroperoxide-Induced Deformability Decrease in Human Erythrocytesen
heal.abstractTreatment of human erythrocytes with micromolar concentrations of tert-butyl hydroperoxide causes changes in the physical properties of the cells as evidenced by decreased deformability. The deformability changes followed a lag period which was reciprocally related to the concentrations of hydroperoxide. Ascorbic acid was able to delay these changes or reverse them for a period of time. Oxidation of ascorbic acid was observed, under the same conditions, which was correlated to the ability of both oxy- and met-forms of haemoglobin to catalyse the oxidation of ascorbic acid by tert-butyl hydroperoxide. It seems likely that ascorbic acid acts both as inhibitor of the oxidative activation of haemoglobin, which leads to deformability changes and as substrate for the haemoglobin catalysed tert-butyl hydroperoxide decomposition.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondary<Go to ISI>://A1995QD99600012-
heal.journalNameClinical Hemorheologyen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1995-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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