Pleiotropic effects of ezetimibe: do they really exist?
| dc.contributor.author | Kalogirou, M. | en |
| dc.contributor.author | Tsimihodimos, V. | en |
| dc.contributor.author | Elisaf, M. S. | en |
| dc.date.accessioned | 2015-11-24T18:58:07Z | |
| dc.date.available | 2015-11-24T18:58:07Z | |
| dc.identifier.issn | 1879-0712 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19248 | |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Anticholesteremic Agents/pharmacology/therapeutic use | en |
| dc.subject | Atherosclerosis/*drug therapy | en |
| dc.subject | Azetidines/*pharmacology/*therapeutic use | en |
| dc.subject | Biological Markers/metabolism | en |
| dc.subject | Disease Models, Animal | en |
| dc.subject | Endothelium, Vascular/drug effects | en |
| dc.subject | Humans | en |
| dc.subject | Inflammation/*drug therapy/metabolism | en |
| dc.subject | Inflammation Mediators | en |
| dc.subject | Lipid Metabolism/*drug effects | en |
| dc.subject | Platelet Aggregation/drug effects | en |
| dc.subject | Treatment Outcome | en |
| dc.title | Pleiotropic effects of ezetimibe: do they really exist? | en |
| heal.abstract | Ezetimibe represents a new lipid lowering agent which inhibits cholesterol absorption. It effectively reduces low-density lipoprotein cholesterol when administered either alone or in combination with statins. However, its effect on cardiovascular mortality remains under question since it failed to demonstrate any significant changes in the primary endpoints of the recently published ENHANCE and SEAS studies. A possible explanation for this unsuccessful outcome is that ezetimibe lacks pleiotropic effects. This article aims to review the potential pleiotropic effects of the drug mainly on inflammation markers, lipoprotein subfractions and endothelial function. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1016/j.ejphar.2010.02.003 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/20152830 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0014299910000865/1-s2.0-S0014299910000865-main.pdf?_tid=66ea5c63c740e7b39c359383c65d1fa6&acdnat=1334038252_e71473eeda77cb3702f5ce4df8928a5e | - |
| heal.journalName | European Journal of Pharmacology | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2010 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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