Immature rat convulsions and long-term effects on hippocampal cholinergic neurotransmission
| dc.contributor.author | Meilleur, S. | en |
| dc.contributor.author | Carmant, L. | en |
| dc.contributor.author | Psarropoulou, C. | en |
| dc.date.accessioned | 2015-11-24T16:32:23Z | |
| dc.date.available | 2015-11-24T16:32:23Z | |
| dc.identifier.issn | 0959-4965 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/7549 | |
| dc.rights | Default Licence | - |
| dc.subject | cholinergic | en |
| dc.subject | development | en |
| dc.subject | epilepsy | en |
| dc.subject | eserine | en |
| dc.subject | hippocampus | en |
| dc.subject | ontogenesis | en |
| dc.subject | seizures | en |
| dc.subject | pentylenetetrazol-induced seizures | en |
| dc.subject | chronically epileptic rats | en |
| dc.subject | acetylcholine-release | en |
| dc.subject | inhibition | en |
| dc.subject | activation | en |
| dc.subject | responses | en |
| dc.subject | receptors | en |
| dc.subject | increase | en |
| dc.subject | decrease | en |
| dc.subject | brain | en |
| dc.title | Immature rat convulsions and long-term effects on hippocampal cholinergic neurotransmission | en |
| heal.abstract | Generalized tonic-clonic convulsions were induced on 2 consecutive days by pentylenetetrazol (PTZ) in immature rats (postnatal days 10 and 20), and hippocampal slices were prepared at different intervals post-injection. The anticholinesterase eserine provoked interictal-like discharges in the CA3 area of PTZ-injected rats (19/33), but not in controls (0/15), an effect mimicked by carbachol and reversed by atropine. This enhanced response to eserine Was recorded in slices from 25-100% of the PTZ-injected rats, the percentage varying with the age at injection and post-injection interval. These results suggest that seizures in immature brain may have long-term consequences in cholinergic neurotransmission, converting a rise in endogenous ACh into an epileptogenic stimulus, which in turn would presumably facilitate the recurrence of seizures. NeuroReport 11:521-524 (C) 2000 Lippincott Williams & Wilkins. Ins. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | <Go to ISI>://000085486900021 | - |
| heal.identifier.secondary | http://graphics.tx.ovid.com/ovftpdfs/FPDDNCJCOCEGCA00/fs004/ovft/live/gv006/00001756/00001756-200002280-00019.pdf | - |
| heal.journalName | Neuroreport | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2000 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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