Lipid abnormalities in chronic uremic patients. Response to treatment with gemfibrozil
Φόρτωση...
Ημερομηνία
Συγγραφείς
Elisaf, M. S.
Dardamanis, M. A.
Papagalanis, N. D.
Siamopoulos, K. C.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Scand J Urol Nephrol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Seventy-four patients with end stage renal failure were studied. Forty-six of them were on hemodialysis (HD) while 28 were on continuous ambulatory peritoneal dialysis (CAPD). In addition 56 nondialysis chronic renal failure (NDCRF) patients with various degree of renal failure were also studied. In all groups serum triglyceride concentrations were significantly higher and HDL cholesterol concentrations were significantly lower compared to age- and sex-matched controls. Total and LDL cholesterol were significantly higher in the NDCRF and CAPD patients compared to controls. In 55 patients (20 on HD, 13 on CAPD and 22 NDCRF) with severe hypertriglyceridemia or diminished HDL cholesterol gemfibrozil 300 mg b.i.d. per os was given for 6 months. Drug treatment reduced significantly serum triglycerides in all groups of patients and increased the levels of HDL cholesterol in CAPD patients. Moreover, a statistically significant decrease of the levels of total and LDL cholesterol was noticed in HD and NDCRF patients. During treatment no significant side effects were observed and liver and muscle enzymes remained within normal values.
Περιγραφή
Λέξεις-κλειδιά
Adult, Aged, Cholesterol, HDL/blood, Female, Gemfibrozil/*therapeutic use, Humans, Hypercholesterolemia/blood/drug therapy, Hyperlipidemias/blood/*drug therapy, Hypertriglyceridemia/blood/drug therapy, Kidney Failure, Chronic/blood/*drug therapy, Lipids/*blood, Male, Middle Aged, *Peritoneal Dialysis, Continuous Ambulatory, *Renal Dialysis, Triglycerides/blood, Uremia/blood/*drug therapy
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/8493456
http://informahealthcare.com/doi/abs/10.3109/00365599309180423
http://informahealthcare.com/doi/abs/10.3109/00365599309180423
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής