Combined HLA-DR and -DQ disparity is associated with a stable course of ulcerative colitis after liver transplantation for primary sclerosing cholangitis

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dc.contributor.authorCholongitas, E.en
dc.contributor.authorPapatheodoridis, G. V.en
dc.contributor.authorZappoli, P.en
dc.contributor.authorGiannakopoulos, A.en
dc.contributor.authorPatch, D.en
dc.contributor.authorMarelli, L.en
dc.contributor.authorShusang, V.en
dc.contributor.authorKalambokis, G.en
dc.contributor.authorShirling, G.en
dc.contributor.authorRolando, N.en
dc.contributor.authorBurroughs, A. K.en
dc.date.accessioned2015-11-24T19:29:24Z
dc.date.available2015-11-24T19:29:24Z
dc.identifier.issn1527-6465-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22969
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectCholangiocarcinoma/epidemiologyen
dc.subjectCholangitis, Sclerosing/*surgeryen
dc.subjectColitis, Ulcerative/*immunologyen
dc.subjectFemaleen
dc.subjectHLA-DQ Antigens/*immunologyen
dc.subjectHLA-DR Antigens/*immunologyen
dc.subjectHistocompatibility Testingen
dc.subjectHumansen
dc.subjectLiver Neoplasms/epidemiologyen
dc.subjectLiver Transplantation/*immunologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPostoperative Complications/*immunologyen
dc.subjectRetrospective Studiesen
dc.subjectTreatment Outcomeen
dc.titleCombined HLA-DR and -DQ disparity is associated with a stable course of ulcerative colitis after liver transplantation for primary sclerosing cholangitisen
heal.abstractCombined disparity of human leukocyte antigen (HLA)-DR and -DQ between mother and fetus is associated with less severe ulcerative colitis (UC) during pregnancy. We evaluated whether donor-recipient HLA disparity after liver transplantation (LT) affects UC in patients with primary sclerosing cholangitis (PSC). Sixty-nine consecutive patients with PSC underwent LT; all underwent colonoscopy before LT; 48 had UC before and 3 had de novo UC after LT. Clinical and laboratory data, activity and treatment of UC, post-LT cytomegalovirus infection, and disparity of HLA-A, -B, -DR, and -DQ for each donor-recipient pair were evaluated. Pre-LT quiescent UC was present in 26 patients. Post-LT UC activity was evaluated in 36 of 51 patients with UC who had not undergone pre-LT colectomy and who had >12 months' post-LT survival. Of these, 16 were stable, 17 had worsened, and 3 had de novo UC. Seven required colectomy (4 for dysplasia or cancer) after LT. Post-LT cytomegalovirus viremia was neither associated with worse UC activity (P = 0.58) nor de novo UC. Disparity with respect to HLA-A, -B, -DR, and -DQ was found in 58%, 27%, 44%, and 39% donor-recipient pairs, respectively. Post-LT UC course was similar with respect to single HLA disparity. However, disparity in none or only one HLA-DR or -DQ was significantly associated with worse activity compared with patients with disparity at both (65% vs. 0%, P = 0.009). Logistic regression found that the disparity for both -DR and -DQ was the only factor statistically significantly associated with post-LT UC activity. We conclude that disparity in both HLA-DR and -DQ between donor and recipient is associated with stable UC activity after LT.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1002/lt.21077-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17394153-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1002/lt.21077/asset/21077_ftp.pdf?v=1&t=h0ull8ib&s=c3452dedaa6286ecfed68b7d155f3c6392c99b7c-
heal.journalNameLiver Transplen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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