Evaluation of meningioma aggressiveness by (99m)Tc-Tetrofosmin SPECT

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dc.contributor.authorAlexiou, G. A.en
dc.contributor.authorVartholomatos, G.en
dc.contributor.authorTsiouris, S.en
dc.contributor.authorPapadopoulos, A.en
dc.contributor.authorKyritsis, A. P.en
dc.contributor.authorPolyzoidis, K. S.en
dc.contributor.authorVoulgaris, S.en
dc.contributor.authorFotopoulos, A. D.en
dc.date.accessioned2015-11-24T19:17:46Z
dc.date.available2015-11-24T19:17:46Z
dc.identifier.issn0303-8467-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21807
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectCell Cycleen
dc.subjectFemaleen
dc.subjectFlow Cytometryen
dc.subjectHumansen
dc.subjectMagnetic Resonance Imagingen
dc.subjectMaleen
dc.subjectMeningeal Neoplasms/radiography/*radionuclide imagingen
dc.subjectMeningioma/radiography/*radionuclide imagingen
dc.subjectMiddle Ageden
dc.subjectNeoplasm Invasivenessen
dc.subjectOrganophosphorus Compounds/*diagnostic useen
dc.subjectOrganotechnetium Compounds/*diagnostic useen
dc.subjectReproducibility of Resultsen
dc.subjectTomography, Emission-Computed, Single-Photon/*methodsen
dc.subjectTomography, X-Ray Computeden
dc.titleEvaluation of meningioma aggressiveness by (99m)Tc-Tetrofosmin SPECTen
heal.abstractOBJECTIVES: Although meningiomas usually have a benign clinical course, atypical and malignant types of this brain tumor are associated with high recurrence rates and poor outcome; thus, DNA ploidy and S-phase -- as determined by DNA flow cytometry -- are useful indicators of their biological behavior. Brain single-photon emission computed tomography (SPECT) has been suggested as a potentially useful modality for the metabolic assessment of various brain tumors. This study evaluated whether (99m)Tc-Tetrofosmin ((99m)Tc-TF) uptake correlates with meningioma proliferative activity, as assessed by flow cytometry analysis. PATIENTS AND METHODS: Ten consecutive patients (3 males, 7 females, mean age 64.6 years) with a diagnosis of a symptomatic intracranial meningioma, planned to undergo surgery, were studied. Brain SPECT by (99m)Tc-TF was performed within a week prior to surgical excision and flow cytometric analysis was performed in the excised tissue. Tumoral radiotracer accumulation was first assessed visually. Semiquantitative image analysis was also performed, by calculating the lesion-to-normal (L/N) uptake ratio. RESULTS: Benign meningiomas were diagnosed in 8/10 cases, the remaining 2/10 patients had anaplastic lesions. DNA aneuploidy was found in 2 lesions, the remaining tumors were diploid. There was a significant correlation between tracer uptake and the percentage of the cell fraction on S-phase (r=0.733, P=0.05). There was also a positive correlation between tracer uptake and the level of aneuploidy and tumor grade. CONCLUSION: These results imply that (99m)Tc-TF brain SPECT may have the ability to discriminate benign meningiomas from malignant meningiomas pre-operatively, the tracer uptake being a likely indicator of their proliferative activity.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.clineuro.2008.03.016-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/18471956-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0303846708001157/1-s2.0-S0303846708001157-main.pdf?_tid=32fd7225f091a87d50a6e3eb5078f2c8&acdnat=1332758407_ae760fb45a70e9c1bd06051e754957eb-
heal.journalNameClin Neurol Neurosurgen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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