A new concept of melanocytic neoplasia pathogenesis based on the phenotype of common acquired nevi

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dc.contributor.authorBatistatou, A.en
dc.contributor.authorZioga, A.en
dc.contributor.authorPanelos, J.en
dc.contributor.authorMassi, D.en
dc.contributor.authorAgnantis, N. J.en
dc.contributor.authorCharalabopoulos, K.en
dc.date.accessioned2015-11-24T19:40:11Z
dc.date.available2015-11-24T19:40:11Z
dc.identifier.issn0306-9877-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24310
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectCadherins/biosynthesisen
dc.subjectDysplastic Nevus Syndrome/pathologyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectImmunohistochemistry/methodsen
dc.subjectMaleen
dc.subjectMelanocytes/*metabolismen
dc.subjectMelanoma/*etiology/pathologyen
dc.subjectMiddle Ageden
dc.subjectNeoplasms/*pathologyen
dc.subjectNevus, Pigmented/*pathologyen
dc.subjectPrecancerous Conditions/pathologyen
dc.subjectRisk Factorsen
dc.subjectSkin Neoplasms/*etiology/pathologyen
dc.titleA new concept of melanocytic neoplasia pathogenesis based on the phenotype of common acquired nevien
heal.abstractCommon melanocytic nevi are ubiquitous lesions which in some cases constitute a risk factor for the development of melanoma. To date, despite long term research there are no known molecular hallmarks for nevus development. We have observed that common acquired nevi excised from the same individual share remarkable similarity in their microscopic appearance and in the immunohistochemical expression of E-cadherin. Based on these observations, we hypothesize that all melanocytes are genetically similar in the same individual and changes predisposing to neoplasia are a global melanocytic event characteristic for each person and propose a microgenomics/proteomics approach to test this hypothesis.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.mehy.2007.03.004-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17459602-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0306987707002034/1-s2.0-S0306987707002034-main.pdf?_tid=2576a3d221faebc1db6e907cdd4f2750&acdnat=1333346693_5307a0f29aa4f1f949305e4383cc82cb-
heal.journalNameMed Hypothesesen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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