Small dense LDL cholesterol and apolipoproteins C-II and C-III in non-diabetic obese subjects with metabolic syndrome

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dc.contributor.authorFilippatos, T. D.en
dc.contributor.authorTsimihodimos, V.en
dc.contributor.authorKostapanos, M.en
dc.contributor.authorKostara, C.en
dc.contributor.authorBalraktari, E. T.en
dc.contributor.authorKiortsis, D. N.en
dc.contributor.authorTselepis, A. D.en
dc.contributor.authorElisaf, M. S.en
dc.date.accessioned2015-11-24T16:47:27Z
dc.date.available2015-11-24T16:47:27Z
dc.identifier.issn1734-1922-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9185
dc.rightsDefault Licence-
dc.subjectmetabolic syndromeen
dc.subjectapolipoprotein c-iien
dc.subjectapolipoprotein c-iiien
dc.subjectsmall dense ldlen
dc.subjecttriglyceridesen
dc.subjectobesityen
dc.subjectcoronary-heart-diseaseen
dc.subjectlipoprotein-lipaseen
dc.subjecta-ien
dc.subjecttriglyceride levelsen
dc.subjectendothelial-cellsen
dc.subjectapoc-iiien
dc.subjecthypertriglyceridemic subjectsen
dc.subjectmicronized fenofibrateen
dc.subjectcardiovascular risken
dc.subjectphospholipase a(2)en
dc.titleSmall dense LDL cholesterol and apolipoproteins C-II and C-III in non-diabetic obese subjects with metabolic syndromeen
heal.abstractIntroduction: Apolipoprotein (apo) C-II is considered as an important activator of lipoprotein lipase (LPL) and is required for efficient lipolysis of triglyceride (TG)-rich lipoproteins. In contrast, excess apo C-II inhibits LPL-mediated hydrolysis of TGs. Apo C-III is an inhibitor of LPL activity. These effects may influence the plasma levels of atherogenic small dense low-density lipoprotein cholesterol (sdLDL-C), since TG concentrations are markers of this subfraction. Material and methods: We examined the possible influence of apo C-II and C-III plasma levels or sdLDL-C concentration in obese patients with metabolic syndrome (MetS). Plasma apo C-II and C-III were determined by an immunoturbidimetric assay. Obese subjects (n=73) with MetS but without any clinically evident cardiovascular disease were enrolled. Results: TG, apo C-II and C-III plasma levels progressively increased when study participants were divided according to sdLDL-C tertiles (P < 0.001 for all 3 trends). The apo C-III/C-II ratio was relatively constant (i.e. approximate to 2.5) for all tertiles of SdLDL-C. Stepwise multiple linear regression analyses showed that apo C-III levels independently correlated with TG levels, while TG and apo B levels were independently associated with sdLDL-C concentrations. Apo C-II and C-III significantly correlated with sdLDL-C in univariate analysis, but not in multivariate analysis. Conclusions: Apo C-II and C-III levels are not independent predictors of sdLDL-C levels in obese subjects with MetS.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondary<Go to ISI>://000262198500009-
heal.journalNameArchives of Medical Scienceen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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