Proliferation profile of classical Hodgkin's lymphomas. Increased expression of the protein cyclin D2 in Hodgkin's and Reed-Sternberg cells

Simple item page
dc.contributor.authorBai, M.en
dc.contributor.authorTsanou, E.en
dc.contributor.authorAgnantis, N. J.en
dc.contributor.authorKamina, S.en
dc.contributor.authorGrepi, C.en
dc.contributor.authorStefanaki, K.en
dc.contributor.authorRontogianni, D.en
dc.contributor.authorGalani, V.en
dc.contributor.authorKanavaros, P.en
dc.date.accessioned2015-11-24T18:56:08Z
dc.date.available2015-11-24T18:56:08Z
dc.identifier.issn0893-3952-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18990
dc.rightsDefault Licence-
dc.subjectCell Cycle/physiologyen
dc.subject*Cell Proliferationen
dc.subjectCyclin A/biosynthesisen
dc.subjectCyclin B/biosynthesisen
dc.subjectCyclin B1en
dc.subjectCyclin D2en
dc.subjectCyclins/*biosynthesisen
dc.subjectHodgkin Disease/*metabolism/pathologyen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectProliferating Cell Nuclear Antigen/biosynthesisen
dc.subjectReed-Sternberg Cells/*metabolism/pathologyen
dc.subjectTumor Suppressor Protein p53/biosynthesisen
dc.subjectUp-Regulationen
dc.titleProliferation profile of classical Hodgkin's lymphomas. Increased expression of the protein cyclin D2 in Hodgkin's and Reed-Sternberg cellsen
heal.abstractThere is accumulating evidence that Hodgkin's and Reed-Sternberg cells of classical Hodgkin's lymphomas (cHL) display multiple and concurrent alterations in different pathways and checkpoints of the cell cycle. However, the expression of cyclin D2 and its relation to other major cell cycle proteins has not been analyzed in cHL. The aim of the present study was to assess expression of cyclin D2, Ki67, cyclin A, cyclin B1, cyclin D1, cyclin D3, cyclin E, p53, Rb, p16 and p27 proteins in order to gain further insight into the proliferation profile of cHL. Overexpression of cyclin D2 in Hodgkin's and Reed-Sternberg cells was detected in 64/89 (72%) cases of cHL. This finding, in view of recent in vitro data showing that constitutive activation of nuclear factor (NF)-kB could upregulate cyclin D2 expression in part via signal transducer and activator of transcription (STAT)-5a, suggests that induction of cyclin D2 expression may support the proliferation of Hodgkin's and Reed-Sternberg cells. In addition, the present study showed that (1) increased p27 expression status was significantly correlated with higher levels of cyclin A expression (P=0.048) and (2) increased p53 expression status was significantly correlated with higher levels of cyclin A (P<0.001) and cyclin B1 (P=0.040) expression. The association between increased p27 and p53 expression status and higher expression levels of G2/M cyclins suggests that the impairment of the growth inhibitory activity of the p27 and p53 tumor suppressor pathways may promote the proliferation of Hodgkin's and Reed-Sternberg cells.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1038/modpathol.3800183-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15354186-
heal.identifier.secondaryhttp://www.nature.com/modpathol/journal/v17/n11/pdf/3800183a.pdf-
heal.journalNameMod Patholen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2004-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Files

License bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.74 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ