Distribution of the regulatory subunit of type II cAMP-dependent protein kinase in Y-79 retinoblastoma cells. Effect of butyrate
| dc.contributor.author | Kyritsis, A. P. | en |
| dc.contributor.author | Kapoor, C. L. | en |
| dc.contributor.author | Chader, G. J. | en |
| dc.date.accessioned | 2015-11-24T19:24:03Z | |
| dc.date.available | 2015-11-24T19:24:03Z | |
| dc.identifier.issn | 0146-0404 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22409 | |
| dc.rights | Default Licence | - |
| dc.subject | Biological Transport/drug effects | en |
| dc.subject | Butyrates/*pharmacology | en |
| dc.subject | Butyric Acid | en |
| dc.subject | Butyric Acids/*pharmacology | en |
| dc.subject | Carrier Proteins/*metabolism | en |
| dc.subject | Cell Division | en |
| dc.subject | Cell Line | en |
| dc.subject | Cell Nucleolus/metabolism | en |
| dc.subject | Cytoplasm/metabolism | en |
| dc.subject | Eye Neoplasms/*metabolism | en |
| dc.subject | Fluorescent Antibody Technique | en |
| dc.subject | Humans | en |
| dc.subject | *Intracellular Signaling Peptides and Proteins | en |
| dc.subject | Retinoblastoma/*metabolism | en |
| dc.title | Distribution of the regulatory subunit of type II cAMP-dependent protein kinase in Y-79 retinoblastoma cells. Effect of butyrate | en |
| heal.abstract | An indirect immunofluorescence technique was employed to determine the intracellular distribution of the regulatory subunit of type II cyclic adenosine 3':5'-monophosphate-dependent protein kinase (RII) in Y-79 human retinoblastoma cells growing in monolayer culture. During the initial phases of growth (6 hr-6 days after seeding), RII was confined to the cytoplasmic areas of the Y-79 cells, seemingly, the Golgi apparatus. Treatment of cells for 3-5 days with 4 mM butyrate resulted in translocation of RII from cytoplasm to nuclei (mainly nucleoli) of cells. In a later stage of growth (24-day-old cultures), RII immunofluorescence was significantly decreased in all compartments within the untreated cells. In contrast, about 70% of the butyrate-treated cells yet showed nucleoli and/or cytoplasmic localization of RII at this stage. The nucleolar appearance of RII was parallel to the growth arrest and differentiation induced by butyrate. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/3528034 | - |
| heal.journalName | Invest Ophthalmol Vis Sci | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1986 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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