Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation

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dc.contributor.authorKorantzopoulos, P.en
dc.contributor.authorKolettis, T. M.en
dc.contributor.authorKountouris, E.en
dc.contributor.authorDimitroula, V.en
dc.contributor.authorKaranikis, P.en
dc.contributor.authorPappa, E.en
dc.contributor.authorSiogas, K.en
dc.contributor.authorGoudevenos, J. A.en
dc.date.accessioned2015-11-24T19:00:44Z
dc.date.available2015-11-24T19:00:44Z
dc.identifier.issn0167-5273-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19586
dc.rightsDefault Licence-
dc.subjectAdministration, Oralen
dc.subjectAgeden
dc.subjectAntioxidants/*administration & dosageen
dc.subjectAscorbic Acid/*administration & dosageen
dc.subjectAtrial Fibrillation/epidemiology/physiopathology/*therapyen
dc.subjectBiological Markers/blooden
dc.subjectC-Reactive Protein/metabolismen
dc.subjectEchocardiographyen
dc.subjectElectric Countershock/*adverse effectsen
dc.subjectElectrocardiography/drug effectsen
dc.subjectFemaleen
dc.subjectFerritins/blooden
dc.subjectFibrinogen/metabolismen
dc.subjectFollow-Up Studiesen
dc.subjectHeart Atria/ultrasonographyen
dc.subjectHumansen
dc.subjectIncidenceen
dc.subjectInflammation/blood/drug therapy/etiologyen
dc.subjectLeukocyte Counten
dc.subjectMaleen
dc.subjectMyocarditis/blood/*drug therapy/etiologyen
dc.subjectNephelometry and Turbidimetryen
dc.subjectOxidative Stress/physiologyen
dc.subjectProspective Studiesen
dc.subjectRecurrence/prevention & controlen
dc.subjectTreatment Outcomeen
dc.titleOral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammationen
heal.abstractBACKGROUND: Inflammation and oxidative stress have been recently implicated in the pathophysiology of atrial fibrillation (AF). The aim of this study was to examine the potential benefit of vitamin C on the early recurrence rates and on inflammatory indices after successful cardioversion of persistent AF, as well as to investigate the time course of changes in these indices post-cardioversion. METHODS: We prospectively studied 44 consecutive patients after successful electrical cardioversion of persistent AF. All patients received standard treatment and were randomised in one to one fashion to either oral vitamin C administration or no additional therapy. We followed-up the patients for 7 days performing successive measurements of white blood cell (WBC) count, C-reactive protein (CRP), fibrinogen, and ferritin levels. RESULTS: One week after successful cardioversion, AF recurred in 4.5% of patients in the vitamin C group and in 36.3% of patients in the control group (p=0.024). Compared to baseline values, inflammatory indices decreased after cardioversion in patients receiving vitamin C but did not change significantly in the control group. A significant variance was found in the serial measurements of WBC counts (F=5.86, p=0.001) and of fibrinogen levels (F=4.10, p=0.0084) in the two groups. In the vitamin C group CRP levels were lower on the seventh day (p<0.05). CRP and fibrinogen levels were higher in patients who relapsed into AF compared to patients who maintained sinus rhythm (F=2.77, p=0.044 and F=3.51, p=0.017, respectively). CONCLUSIONS: These findings suggest that vitamin C reduces the early recurrence rates after cardioversion of persistent AF and attenuates the associated low-level inflammation. These effects indicate that therapeutic approaches targeting at inflammation and oxidative stress may exert favourable effects on atrial electrical remodeling.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.ijcard.2004.12.041-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15982504-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0167527305002779/1-s2.0-S0167527305002779-main.pdf?_tid=a7d156dde654f25f2500d9b53b3585f0&acdnat=1333963333_7ace665c0cbaa911eeee237ba9165e66-
heal.journalNameInt J Cardiolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2005-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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