C-Reactive protein concentrations and angiographic characteristics of coronary lesions

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dc.contributor.authorKatritsis, D.en
dc.contributor.authorKorovesis, S.en
dc.contributor.authorGiazitzoglou, E.en
dc.contributor.authorParissis, J.en
dc.contributor.authorKalivas, P.en
dc.contributor.authorWebb-Peploe, M. M.en
dc.contributor.authorIoannidis, J. P.en
dc.contributor.authorHaliassos, A.en
dc.date.accessioned2015-11-24T19:26:23Z
dc.date.available2015-11-24T19:26:23Z
dc.identifier.issn0009-9147-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22717
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectAngina, Unstable/diagnosis/radiographyen
dc.subjectBiological Markers/blooden
dc.subjectC-Reactive Protein/*analysisen
dc.subjectCoronary Angiographyen
dc.subjectCoronary Disease/*diagnosis/radiographyen
dc.subjectCross-Sectional Studiesen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectImmunoassayen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNephelometry and Turbidimetryen
dc.subjectRisken
dc.titleC-Reactive protein concentrations and angiographic characteristics of coronary lesionsen
heal.abstractBACKGROUND: C-Reactive protein (CRP) is a strong predictor of clinical outcome in coronary artery disease (CAD), and inflammation has been implicated in the process. We aimed to evaluate whether CRP concentrations measured with a new, automated particle-enhanced immunoturbidimetric method for high-sensitivity CRP may be related to specific high-risk angiographic features of coronary lesions. METHODS: In a cross-sectional study, we examined 103 consecutive patients undergoing cardiac catheterization for suspected CAD. We assessed the association of preprocedural CRP concentrations with clinical presentation (unstable angina) and angiographic features of coronary lesions. RESULTS: Twenty patients had unstable angina. Independent predictors of unstable angina included increased CRP [odds ratio (OR), 2.93 per 10-fold increase in CRP; 95% confidence interval (CI), 1.28-6.69; P = 0.01] and the presence of macroscopic thrombus (OR, 7.08; 95% CI, 1.33-37.8; P = 0.02). Thirty-two culprit lesions had macroscopic thrombus or eccentric/irregular discrete morphology without total occlusion. Increased CRP was the strongest predictor of such features (OR, 2.04 per 10-fold increase in CRP; 95% CI, 1.03-4.04; P = 0.04), and the effect was independent of the presence of unstable angina. CONCLUSIONS: Among patients with suspected CAD undergoing coronary angiography, increased CRP is strongly associated with unstable angina and with specific high-risk features of the culprit coronary lesions.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/11325892-
heal.identifier.secondaryhttp://www.clinchem.org/content/47/5/882.full.pdf-
heal.journalNameClin Chemen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2001-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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