Expression of epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) in gastric and colorectal carcinomas. An immunohistological study of 63 cases

Απλή σελίδα τεκμηρίου
dc.contributor.authorKarameris, A.en
dc.contributor.authorKanavaros, P.en
dc.contributor.authorAninos, D.en
dc.contributor.authorGorgoulis, V.en
dc.contributor.authorMikou, G.en
dc.contributor.authorRokas, T.en
dc.contributor.authorNiotis, M.en
dc.contributor.authorKalogeropoulos, N.en
dc.date.accessioned2015-11-24T19:16:40Z
dc.date.available2015-11-24T19:16:40Z
dc.identifier.issn0344-0338-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21695
dc.rightsDefault Licence-
dc.subjectAdenocarcinoma/*chemistry/pathology/secondaryen
dc.subjectCell Differentiation/physiologyen
dc.subjectColorectal Neoplasms/*chemistry/pathologyen
dc.subjectEpidermal Growth Factor/*analysisen
dc.subjectHumansen
dc.subjectImmunoenzyme Techniquesen
dc.subjectLymphatic Metastasisen
dc.subjectNeoplasm Invasivenessen
dc.subjectReceptor, Epidermal Growth Factor/*analysisen
dc.subjectRetrospective Studiesen
dc.subjectStomach Neoplasms/*chemistry/pathologyen
dc.titleExpression of epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) in gastric and colorectal carcinomas. An immunohistological study of 63 casesen
heal.abstractImmunohistochemical study for epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) was performed on paraffin-embedded tissue specimens from 39 colorectal and 24 gastric carcinomas. The carcinomas were placed in one of the following 3 groups: group 1, neither EGF nor EGFR was stained (11 gastric and 21 colorectal carcinomas); group 2, either EGF or EGFR was stained (4 gastric and 4 colorectal carcinomas); and group 3, both EGF and EGFR were stained (9 gastric and 14 colorectal carcinomas). Compared with the carcinomas in groups 1 and 2, those in group 3 had significantly higher rates of lymph node spread and serosal invasion of the gastrointestinal wall. In contrast, no significant differences were found between the EGF and/or EGFR expression and histological differentiation of carcinomas. These results suggest that gastrointestinal carcinomas expressing both EGF and EGFR display pathological features of more aggressive disease. Furthermore, the synchronous expression of EGF and EGFR indicates that these carcinomas may regulate their growth by an autocrine and/or paracrine mechanism.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/8321742-
heal.journalNamePathol Res Practen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1993-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ