Ligands of four receptors in the nuclear steroid/thyroid hormone superfamily inhibit induction of rat cytosolic aldehyde dehydrogenase-3 (ALDH3c) by 3-methylcholanthrene

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dc.contributor.authorKarageorgou, M.en
dc.contributor.authorVasiliou, V.en
dc.contributor.authorNebert, D. W.en
dc.contributor.authorMarselos, M.en
dc.date.accessioned2015-11-24T19:07:17Z
dc.date.available2015-11-24T19:07:17Z
dc.identifier.issn0006-2952-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20419
dc.rightsDefault Licence-
dc.subjectAldehyde Dehydrogenase/*biosynthesisen
dc.subjectAnimalsen
dc.subjectCarcinogens/*pharmacologyen
dc.subjectDrug Interactionsen
dc.subjectEnzyme Induction/drug effectsen
dc.subjectHormones/*pharmacologyen
dc.subjectLiver/*drug effects/enzymology/metabolismen
dc.subjectMaleen
dc.subjectMethylcholanthrene/*pharmacologyen
dc.subjectRatsen
dc.subjectRats, Wistaren
dc.subjectReceptors, Aryl Hydrocarbon/metabolismen
dc.subjectReceptors, Cell Surface/*drug effects/metabolismen
dc.titleLigands of four receptors in the nuclear steroid/thyroid hormone superfamily inhibit induction of rat cytosolic aldehyde dehydrogenase-3 (ALDH3c) by 3-methylcholanthreneen
heal.abstractUsing six ligands that bind to four different receptors in the nuclear steroid/thyroid hormone superfamily, we have examined the effects of these chemicals on induction of the cytosolic aldehyde dehydrogenase (ALDH3c) activity by 3-methylcholanthrene (3MC) in rat liver and uterus. In contrast to negligible activities in the untreated rat, ALDH3c enzyme activities are induced after a single dose of 3MC. Hepatic ALDH3c induction is decreased 60% to 90% when 3MC is administered together with any of the following ligands: estradiol, testosterone, progesterone, hydrocortisol, diethylstilbestrol, or tamoxifen. None of these same doses of chemicals, administered alone, affects ALDH3c enzyme activity. In addition, when these ligands are injected 2 days after 3MC, no changes are observed in liver or uterus ALDH3c induction. These results suggest that ligands that bind to different receptors in the nuclear steroid/thyroid hormone superfamily might inhibit the ALD3H3c induction process by polycyclic aromatic hydrocarbons; the molecular mechanism(s) of this inhibitory effect is not yet understood.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/8849341-
heal.identifier.secondaryhttp://ac.els-cdn.com/0006295295020853/1-s2.0-0006295295020853-main.pdf?_tid=c5e9512aa1c5c4b50f1cfb8ac59d3ceb&acdnat=1332743108_9ef1a5ef327d6d1754e56f623536ee4b-
heal.journalNameBiochem Pharmacolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1995-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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