Cytokine and adhesion molecule expression evolves between the neutrophilic and lymphocytic phases of viral meningitis

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dc.contributor.authorMakis, A.en
dc.contributor.authorShipway, D.en
dc.contributor.authorHatzimichael, E.en
dc.contributor.authorGalanakis, E.en
dc.contributor.authorPshezhetskiy, D.en
dc.contributor.authorChaliasos, N.en
dc.contributor.authorStebbing, J.en
dc.contributor.authorSiamopoulou, A.en
dc.date.accessioned2015-11-24T19:25:32Z
dc.date.available2015-11-24T19:25:32Z
dc.identifier.issn1557-7465-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22633
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectCell Adhesion Molecules/biosynthesis/blood/cerebrospinal fluid/geneticsen
dc.subjectCerebrospinal Fluid/cytology/immunology/*metabolism/virologyen
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectEnterovirus/*immunology/pathogenicityen
dc.subjectFemaleen
dc.subjectGene Expression Regulation/immunologyen
dc.subjectHumansen
dc.subjectInfanten
dc.subjectInterleukin-12/biosynthesis/blood/cerebrospinal fluid/geneticsen
dc.subjectInterleukin-4/biosynthesis/blood/cerebrospinal fluid/geneticsen
dc.subjectLeukocytosisen
dc.subjectLymphocytes/immunology/*metabolism/pathology/virologyen
dc.subjectMaleen
dc.subjectMeningitis, Viral/blood/cerebrospinal fluid/*immunology/physiopathologyen
dc.subjectNeutrophils/immunology/*metabolism/pathology/virologyen
dc.subjectTh1-Th2 Balanceen
dc.titleCytokine and adhesion molecule expression evolves between the neutrophilic and lymphocytic phases of viral meningitisen
heal.abstractViral meningitis is characterized by cerebrospinal fluid (CSF) lymphocyte pleocytosis, although neutrophils may predominate in the early phase. The T helper 1 (Th1)/Th2 cytokine balance and expression of adhesion molecules seem to be involved in the CSF chemotaxis. We aimed to determine expression of cytokines and adhesion molecules in enteroviral meningitis. We investigated the serum and CSF levels of adhesion molecules (E-selectin, L-selectin, vascular cell adhesion molecule-1 [VCAM-1], and intracellular adhesion molecule-1 [ICAM-1]) and cytokines (interleukin-12 [IL-12] and IL-4) in 105 children during an outbreak of enteroviral meningitis. Diagnosis was confirmed with positive polymerase chain reaction (PCR) and/or serology for echovirus or Coxsackie virus, and matched with control subjects for clinical features but with negative PCR and/or serology. Apart from VCAM-1, the CSF levels of all investigated inflammatory molecules were significantly increased. In serum, sL-selectin and ICAM-1 levels were significantly higher than control subjects. Serum and CSF L-selectin, serum VCAM-1, and CSF IL-12 were all observed to be expressed in significantly higher levels in the neutrophil-dominant subgroup (72% had duration of symptoms <24 h) than in the lymphocyte-dominant group (87.5% had duration of symptoms >24 h). Serum and CSF ICAM-1 was found at significantly higher levels in the latter group. Evolving expression of adhesion molecules and cytokines indicates a shift from Th1 to Th2 immune responses as infection progresses.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1089/jir.2009.0113-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/20626298-
heal.identifier.secondaryhttp://online.liebertpub.com/doi/abs/10.1089/jir.2009.0113-
heal.journalNameJ Interferon Cytokine Resen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2010-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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