Study of growth hormone secretion and action in growth-retarded children with juvenile chronic arthritis (JCA)

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dc.contributor.authorTsatsoulis, A.en
dc.contributor.authorSiamopoulou, A.en
dc.contributor.authorPetsoukis, C.en
dc.contributor.authorChalla, A.en
dc.contributor.authorBairaktari, E.en
dc.contributor.authorSeferiadis, K.en
dc.date.accessioned2015-11-24T18:50:14Z
dc.date.available2015-11-24T18:50:14Z
dc.identifier.issn1096-6374-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18048
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAdrenergic alpha-Agonists/pharmacologyen
dc.subjectArthritis, Juvenile Rheumatoid/*metabolismen
dc.subjectChilden
dc.subjectClonidine/pharmacologyen
dc.subjectFemaleen
dc.subjectGlucose Tolerance Testen
dc.subjectGrowth Disorders/metabolismen
dc.subjectGrowth Hormone/pharmacology/*secretionen
dc.subjectHumansen
dc.subjectInsulin-Like Growth Factor Binding Protein 3/blooden
dc.subjectInsulin-Like Growth Factor I/analysis/biosynthesisen
dc.subjectMaleen
dc.subjectTime Factorsen
dc.titleStudy of growth hormone secretion and action in growth-retarded children with juvenile chronic arthritis (JCA)en
heal.abstractThe stimulated and spontaneous growth hormone (GH) secretion and the response to GH action were assessed in growth-retarded children with juvenile chronic arthritis (JCA), in order to determine the underlying mechanisms of growth retardation in such children. Six children (4 boys and 2 girls aged 10.7-13.8 years) with active JCA of systemic onset were included in the study which involved: (1) anthropometric measurements; (2) assessment of GH responses to insulin-induced hypoglycaemia and clonidine stimulation; (3) assessment of the nocturnal pulsatile GH secretion by measuring GH in blood samples obtained every 20 min from 20.00 to 08.00 h; and (4) the IGF-I generation test. As a control, the latter test was also performed in eight aged-matched children with physiological delay in puberty. Biosynthetic hGH (0.1 IU/kg BW) was administered s. c. for 4 days and blood samples were taken at baseline and the morning after the last GH injection for measurement of IGF-I and IGFBP-3. All six children with JCA were prepubertal and their growth velocity was <3 cm/year. The GH responses to both stimulation tests were normal (peak GH >20 mU/l). Analysis of the pulsatile GH secretion during the night revealed three-to-four GH pulses of normal amplitude (>20 mU/l). IGF-I (26.7+/-4.6 nmol/l, mean+/-SD) and IGFBP-3 (2.1+/-0.2 mg/l) levels were lower in the patients compared with the controls (43.0+/-3.7 nmol/l and 2.8+/-0.2 mg/l, respectively, P<0.01). Following stimulation with exogenous hGH, there was a significant increase in IGF-I and IGFBP-3 levels in the control group (85 and 73%, respectively), but only a small increase in the patients (31 and 14%). It appears that stimulated and spontaneous GH secretion is normal in children with active systemic JCA, but the response to endogenous and exogenous GH with regard to IGF-I and IGFBP-3 production is impaired, indicating a degree of GH insensitivity in such children.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1054/ghir.1999.0099-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/10373347-
heal.identifier.secondaryhttp://ac.els-cdn.com/S1096637499900990/1-s2.0-S1096637499900990-main.pdf?_tid=acdadf40106465d449383b2693074148&acdnat=1337336443_1f0488282f262dfef02d9c6118d7fd99-
heal.journalNameGrowth Horm IGF Resen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1999-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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