Is there a role for PDE5 inhibitors in the management of male infertility due to defects in testicular or epididymal function?

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dc.contributor.authorDimitriadis, F.en
dc.contributor.authorTsounapi, P.en
dc.contributor.authorSaito, M.en
dc.contributor.authorWatanabe, T.en
dc.contributor.authorSylakos, A.en
dc.contributor.authorTsabalas, S.en
dc.contributor.authorMiyagawa, I.en
dc.contributor.authorSofikitis, N.en
dc.date.accessioned2015-11-24T19:08:47Z
dc.date.available2015-11-24T19:08:47Z
dc.identifier.issn1873-4286-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20593
dc.rightsDefault Licence-
dc.subjectAcrosome Reaction/drug effectsen
dc.subjectCyclic GMP/metabolismen
dc.subjectCyclic Nucleotide Phosphodiesterases, Type 5/biosynthesisen
dc.subjectEpididymis/*physiopathologyen
dc.subjectGenital Diseases, Male/*complications/*drug therapy/physiopathologyen
dc.subjectGenitalia, Male/metabolismen
dc.subjectHumansen
dc.subjectInfertility, Male/*drug therapy/enzymology/*etiologyen
dc.subjectLeydig Cells/metabolismen
dc.subjectMaleen
dc.subject*Phosphodiesterase 5 Inhibitorsen
dc.subjectPhosphodiesterase Inhibitors/*therapeutic useen
dc.subjectSemen/cytology/drug effectsen
dc.subjectSeminiferous Tubules/metabolismen
dc.subjectSertoli Cells/metabolismen
dc.subjectSperm Capacitation/drug effectsen
dc.subjectSpermatozoa/drug effectsen
dc.subjectTesticular Diseases/*complications/*drug therapyen
dc.titleIs there a role for PDE5 inhibitors in the management of male infertility due to defects in testicular or epididymal function?en
heal.abstractThis review study refers to the possibility to employ PDE5 inhibitors as an adjunct tool for the therapeutic management of male infertility. The literature tends to suggest that PDE5 inhibitors enhance the Leydig cell secretory function and play a role in the regulation of the contractility of the tunica albuginea and the epididymis. In addition, the literature suggests that PDE5 inhibitors increase the prostatic secretory function that results in an improvement in sperm motility in several cases. Some studies additionally demonstrate a role of PDE5 inhibitors in the regulation of sperm capacitation process. Additional placebo-controlled, randomized, blind studies are necessary to unequivocally suggest a therapeutic role of PDE5 inhibitors in the alleviation of semen disorders and male infertility.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19860697-
heal.journalNameCurr Pharm Desen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2009-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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