Microsurgical repair after crush-avulsion injury of the femoral vein in rats: prevention of microvascular thrombosis with recombinant human tissue-type plasminogen activator (rt-PA)
| dc.contributor.author | Lykoudis, E. G. | en |
| dc.contributor.author | Contodimos, G. B. | en |
| dc.contributor.author | Tsoutsos, D. A. | en |
| dc.contributor.author | Frangia, K. B. | en |
| dc.contributor.author | Papalois, A. E. | en |
| dc.contributor.author | Stamatopoulos, C. N. | en |
| dc.contributor.author | Ioannovich, J. D. | en |
| dc.date.accessioned | 2015-11-24T19:04:24Z | |
| dc.date.available | 2015-11-24T19:04:24Z | |
| dc.identifier.issn | 0738-1085 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20032 | |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Femoral Vein/injuries/*surgery | en |
| dc.subject | Male | en |
| dc.subject | Microsurgery | en |
| dc.subject | Plasminogen Activators/*therapeutic use | en |
| dc.subject | Rats | en |
| dc.subject | Rats, Wistar | en |
| dc.subject | Tissue Plasminogen Activator/*therapeutic use | en |
| dc.subject | Vascular Patency | en |
| dc.subject | Venous Thrombosis/*prevention & control | en |
| dc.title | Microsurgical repair after crush-avulsion injury of the femoral vein in rats: prevention of microvascular thrombosis with recombinant human tissue-type plasminogen activator (rt-PA) | en |
| heal.abstract | Vein thrombosis is often encountered in microsurgery, especially in the case of crush-avulsion injuries. The aim of this study was to investigate the effect of systemic administration of recombinant tissue-type plasminogen activator (rt-PA) on the patency of the femoral vein of the rat, which had previously sustained a crush-avulsion injury. The study consisted of 3 groups of male Wistar rats, 20 animals each. A standardized crush-avulsion injury model was used. After microvascular repair of the femoral vein, the animals received either normal saline (group A), heparin 100 U/kg body weight (group B), or rt-PA 3.5 mg/kg body weight (group C) systemically. Patency tests were performed at 20 minutes, 48 hours, and 1 week after blood flow reestablishment. According to our results, the patency rate of the rt-PA group was significantly higher than in both the control and heparin groups. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/11757061 | - |
| heal.journalName | Microsurgery | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2001 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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