Action mechanism of anticonvulsant and anti-immobility (forced swim) effects of 3', 4'-dihydro-N, N-dimethylspiro-[9H-fluorene-9, 2' (5'H) furane]-3'-methanamine (AE37F)
| dc.contributor.author | Vamvakides, A. | en |
| dc.contributor.author | Antoniou, K. | en |
| dc.contributor.author | Daifoti, Z. | en |
| dc.date.accessioned | 2015-11-24T19:38:14Z | |
| dc.date.available | 2015-11-24T19:38:14Z | |
| dc.identifier.issn | 0003-4509 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/24127 | |
| dc.rights | Default Licence | - |
| dc.subject | Amantadine/pharmacology | en |
| dc.subject | Animals | en |
| dc.subject | Anticonvulsants/*pharmacology | en |
| dc.subject | Brain Chemistry/drug effects | en |
| dc.subject | Convulsants/pharmacology | en |
| dc.subject | Furans/*pharmacology | en |
| dc.subject | Hydroxyindoleacetic Acid/metabolism | en |
| dc.subject | Mice | en |
| dc.subject | Motor Activity/drug effects | en |
| dc.subject | Muscarinic Antagonists/chemical synthesis/pharmacology | en |
| dc.subject | Pentylenetetrazole/antagonists & inhibitors/pharmacology | en |
| dc.subject | Rats | en |
| dc.subject | Receptors, N-Methyl-D-Aspartate/drug effects | en |
| dc.subject | Serotonin/metabolism | en |
| dc.subject | Spiro Compounds/*pharmacology | en |
| dc.subject | Swimming/psychology | en |
| dc.title | Action mechanism of anticonvulsant and anti-immobility (forced swim) effects of 3', 4'-dihydro-N, N-dimethylspiro-[9H-fluorene-9, 2' (5'H) furane]-3'-methanamine (AE37F) | en |
| heal.abstract | AE37F, a new aminotetrahydrofuranic derivative, exhibited, at 10-30 mg/Kg (po) or 1-10 mg/Kg (ip), antagonism of tonic convulsions, induced by pentetrazole (130 mg/Kg, ip), and of forced swin immobility, in mice. At these doses AE37F induced a considerable (100-250%) increase of serotonin (5-HT) and its main metabolite, 5-hydroxyindolacetic acid (5-HIAA), in the rat nucleus reticularis pontis oralis (NRPO), antagonized by amantadine, which also increased 5-HT and 5-HIAA levels in the NRPO. It is suggested: a) that the anti-immobility effect of AE37F is related to its antimuscarinic properties, b) that the rate of 5-HT release in the NRPO, calculated here by a new approach (from the 5-HT and 5-HIAA brain levels) is increased by AE37F and decreased by amantadine, in the NRPO, c) that the anti-convulsant action, observed with AE37F, could be related to a NMDA-sigma mediated stimulation of serotoninergic, GABAergic and glycinergic brain neurones, antagonized by the NMDA-sigma inhibition induced by amantadine. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/14747773 | - |
| heal.journalName | Ann Pharm Fr | en |
| heal.journalType | peer-reviewed | - |
| heal.language | fr | - |
| heal.publicationDate | 2004 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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