Components of the metabolic syndrome and risk for first-ever acute ischemic nonembolic stroke in elderly subjects

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dc.contributor.authorMilionis, H. J.en
dc.contributor.authorRizos, E.en
dc.contributor.authorGoudevenos, J.en
dc.contributor.authorSeferiadis, K.en
dc.contributor.authorMikhailidis, D. P.en
dc.contributor.authorElisaf, M. S.en
dc.date.accessioned2015-11-24T19:28:05Z
dc.date.available2015-11-24T19:28:05Z
dc.identifier.issn1524-4628-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22868
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectApolipoprotein A-I/metabolismen
dc.subjectBrain Ischemia/*pathologyen
dc.subjectCase-Control Studiesen
dc.subjectCholesterol/metabolismen
dc.subjectCholesterol, HDL/metabolismen
dc.subjectDiabetes Complications/pathologyen
dc.subjectDiabetes Mellitus/pathologyen
dc.subjectFemaleen
dc.subjectFibrinogen/metabolismen
dc.subjectHumansen
dc.subjectHypertension/pathologyen
dc.subjectIschemiaen
dc.subjectLipoprotein(a)/metabolismen
dc.subjectLipoproteins, HDL/metabolismen
dc.subjectLogistic Modelsen
dc.subjectMaleen
dc.subjectMetabolic Syndrome X/*diagnosis/pathologyen
dc.subjectObesity/pathologyen
dc.subjectOdds Ratioen
dc.subjectRegression Analysisen
dc.subjectRisk Factorsen
dc.subjectStroke/*diagnosis/pathologyen
dc.subjectTriglycerides/metabolismen
dc.subjectUric Acid/metabolismen
dc.titleComponents of the metabolic syndrome and risk for first-ever acute ischemic nonembolic stroke in elderly subjectsen
heal.abstractBACKGROUND AND PURPOSE: Metabolic syndrome (MetSyn) represents a constellation of lipid and nonlipid risk factors for cardiovascular disease and is a recognized target for increased behavioral therapy. OBJECTIVE: The association between acute ischemic/nonembolic stroke and the MetSyn in elderly individuals was assessed in a population-based case-control study in the prefecture of Ioannina, Greece. STUDY POPULATION: A total of 163 patients aged older than 70 years admitted with first-ever-in-a-lifetime acute ischemic/nonembolic stroke and 166 controls were included. RESULTS: The prevalence of MetSyn (defined according to NCEP/ATP III criteria) was high in stroke patients (46.0% versus 15.7%, P<0.001). Compared with controls as a group (with and without MetSyn), stroke patients with the MetSyn showed higher concentrations of triglycerides, lipoprotein(a), uric acid, and fibrinogen, and lower high-density lipoprotein (HDL) cholesterol and apolipoprotein A-I levels. In logistic regression analysis, crude and adjusted odd ratios (ORs) for MetSyn were 5.33 (95% confidence interval [CI], 2.91 to 9.79; P<0.0001) and 2.59 (95% CI, 1.24 to 5.42; P=0.012), respectively. The analysis of interaction between MetSyn and its individual components revealed significant associations with abdominal obesity (adjusted OR, 2.74; 95% CI, 1.15 to 6.50; P=0.02), hypertension (OR, 2.03; 95% CI, 0.91 to 4.49; P=0.08), high fasting glucose levels (OR, 2.95; 95% CI, 1.19 to 7.35; P=0.02), high triglyceride (OR, 5.55; 95% CI, 2.71 to 11.37; P<0.0001]), and low HDL cholesterol (OR, 5.42; 95% CI, 2.85 to 10.30; P<0.0001). Notably, in stroke patients with the MetSyn the inverse relationship between HDL cholesterol levels and ischemic stroke was negated (OR, 1.04; 95% CI, 1.02 to 1.05; P<0.0001). CONCLUSIONS: MetSyn is associated with an increased risk for acute ischemic/nonembolic stroke in elderly subjects with significant contributions from its individual components. In the presence of MetSyn, HDL cholesterol loses its protective role against ischemic stroke.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1161/01.STR.0000169935.35394.38-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15933255-
heal.identifier.secondaryhttp://stroke.ahajournals.org/content/36/7/1372.full.pdf-
heal.journalNameStrokeen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2005-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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