Acute nateglinide administration in subjects with type 2 diabetes: Effects on postprandial metabolism, coagulation, and fibrinolysis

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dc.contributor.authorTentolouris, N.en
dc.contributor.authorBoutati, E.en
dc.contributor.authorKarambakalis, N.en
dc.contributor.authorPerea, D.en
dc.contributor.authorTselepis, A. D.en
dc.contributor.authorTsoukala, C.en
dc.contributor.authorKyriaki, D.en
dc.contributor.authorLourida, E.en
dc.contributor.authorAnastasopoulou, I.en
dc.contributor.authorKarafoullidou, A.en
dc.contributor.authorRaptis, S. A.en
dc.contributor.authorKatsilambros, N.en
dc.date.accessioned2015-11-24T16:43:17Z
dc.date.available2015-11-24T16:43:17Z
dc.identifier.issn0939-4753-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/8677
dc.rightsDefault Licence-
dc.subjecttype 2 diabetesen
dc.subjectpostprandialen
dc.subjectcoagulationen
dc.subjectfibrinolysisen
dc.subjectlipaemiaen
dc.subjecthyperglycaemiaen
dc.subjectlipoprotein subfractionsen
dc.subjectnateglinideen
dc.subjectfollow-upen
dc.subjectmellitusen
dc.subjectlipoproteinsen
dc.subjectactivationen
dc.subjectmortalityen
dc.subjectinsulinen
dc.subjectniddmen
dc.subjectatherosclerosisen
dc.subjectglibenclamideen
dc.subjectpopulationen
dc.titleAcute nateglinide administration in subjects with type 2 diabetes: Effects on postprandial metabolism, coagulation, and fibrinolysisen
heal.abstractBackground and aim: Postprandial glycaemia and lipaemia are known risk factors for atherosclerosis in type 2 diabetes. Coagulation activation in the postprandial. state also contributes to acceleration of atherosclerosis. Nateglinide is effective in reducing postprandial glycaemia. Its effect on glycaemia may also be beneficial in postprandial lipaemia and coagulation. The aim of this study was to examine the potential effect of a single dose of nateglinide on postprandial triglyceridaemia, coagulation, and fibrinolysis in patients with type 2 diabetes. Methods and results: Ten subjects with type 2 diabetes, treated with diet alone were recruited in a crossover randomized study. In the morning, after a 12- to 14-h fast, each subject received a standard mixed meat (total energy 783 kcal), preceded by one tablet of 120 mg nateglinide or placebo. Venous blood samples were drawn prior to meat consumption and 6 h afterwards for the measurement of plasma glucose, insulin, and C-peptide, lipids, coagulation, and fibrinolysis factors. As expected, there was a significant reduction in postprandial glycaemia after nateglinide administration compared to placebo (P < 0.001). Plasma insulin levels were significantly higher after nateglinide than after placebo (P = 0.002). Nateglinide administration resulted in a lower overall postprandial reduction of tissue-plasminogen activator than placebo (-2.9 ± 1.3 vs. -8.3 ± 3.7 ng/ml h, P = 0.003). In addition, a significant reduction of postprandial plasminogen activator inhibitor-1 was observed in comparison with the baseline values after nateglinide (P = 0.001), although the overall response was not significantly different after nateglinide and placebo (P = 0.31). Plasma concentrations of C-peptide, lipids and the remaining coagulation parameters studied were not different between nateglinide and placebo. Conclusions: Acute nateglinide administration improves postprandial glycaemia and fibrinolytic activity in patients with type 2 diabetes. This combined effect, if confirmed by a long-treatment study, might reduce cardiovascular risk in type 2 diabetes. © 2005 Published by Elsevier Ltd.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1016/j.numecd.2004.06.002-
heal.identifier.secondary<Go to ISI>://000228903000003-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0939475304000031/1-s2.0-S0939475304000031-main.pdf?_tid=7312fb7e8b602c6a5ade404c3bf67034&acdnat=1333111854_a2932f4ff9c04e04ec340f4ac58c9818-
heal.journalNameNutrition Metabolism and Cardiovascular Diseasesen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2005-
heal.publisherElsevieren
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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