Evidence for association of sex hormone-binding globulin and androgen receptor genes with semen quality
Φόρτωση...
Ημερομηνία
Συγγραφείς
Lazaros, L.
Xita, N.
Kaponis, A.
Zikopoulos, K.
Sofikitis, N.
Georgiou, I.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Andrologia
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
The roles of androgen receptor AR(CAG)n gene polymorphisms and sex hormone-binding globulin SHBG(TAAAA)n gene polymorphisms on semen quality were studied. One hundred fourteen men were included in the study: 85 with normal sperm count and 29 oligospermic. The genotype analysis, on DNA extracted from spermatozoa, revealed five SHBG(TAAAA)n alleles with 6-10 repeats and 18 AR(CAG)n alleles with 12-32 repeats. The SHBG allelic distribution showed that in men with normal sperm count and motility, those with short SHBG alleles had higher sperm concentration than men with long SHBG alleles (P = 0.039). As concerns AR(CAG)n polymorphisms, men with short AR alleles had lower sperm motility compared to those with long AR alleles (P < 0.001) in both total study population and normal sperm count men. The synergistic effect analysis of the two polymorphisms revealed an association between sperm motility (P = 0.036), because of the effect of AR(CAG)n polymorphism on sperm motility. In conclusion, long AR alleles were found to be associated with higher sperm motility, while short SHBG alleles were associated with higher sperm concentration, supporting the significance of these genes in spermatogenesis and semen quality.
Περιγραφή
Λέξεις-κλειδιά
Adult, Alleles, Base Sequence, Case-Control Studies, DNA/genetics, DNA Primers/genetics, Genotype, Humans, Male, Microsatellite Repeats, Middle Aged, Oligospermia/etiology/genetics/physiopathology, Polymerase Chain Reaction, Polymorphism, Genetic, Receptors, Androgen/*genetics/physiology, Semen/*cytology/*metabolism, Sex Hormone-Binding Globulin/*genetics/physiology, Sperm Count, Sperm Motility/genetics/physiology, Spermatogenesis/genetics/physiology, Trinucleotide Repeats
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/18477206
http://onlinelibrary.wiley.com/store/10.1111/j.1439-0272.2008.00835.x/asset/j.1439-0272.2008.00835.x.pdf?v=1&t=h0kzqiv1&s=5aa92f11ad5cb6f6becd3d87dcaafd4ddd84b86a
http://onlinelibrary.wiley.com/store/10.1111/j.1439-0272.2008.00835.x/asset/j.1439-0272.2008.00835.x.pdf?v=1&t=h0kzqiv1&s=5aa92f11ad5cb6f6becd3d87dcaafd4ddd84b86a
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής